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alphaTub67C alpha-Tubulin at 67C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39130, updated on 2-Nov-2024

Summary

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Official Symbol
alphaTub67Cprovided by FlyBase
Official Full Name
alpha-Tubulin at 67Cprovided by FlyBase
Primary source
FLYBASE:FBgn0087040
Locus tag
Dmel_CG8308
See related
AllianceGenome:FB:FBgn0087040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4t; 67C; ALPHA 67C; alpha-tub; alpha-Tub; alpha-tub67C; alpha-Tub67C; alpha-tubulin; alpha-Tubulin67C; alpha-tubulin[4]; alpha4; alpha4-t; alpha4-tubulin; alpha4t; alpha4Tub67C; alpha67C; alphatub; alphaTub; alphaTUB; alphaTub 67C; alphaTub4; alphatub67C; alphaTubulin; alphaTub[67C]; aTub67C; CG8308; D.m.ALPHA-67C; Dmel\CG8308; DTA2; Fs(3)Kav; Fs(3)Kavar; Fs(3)Sz14; Fs(3)Sz22; Fs(3)Tom; Fs(3)Tomaj; gamma-Tub; Kavar; mum-tub67C; T; Tom; tub; Tub; Tub1E; tub67c; tubulin
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including embryonic cleavage; microtubule cytoskeleton organization; and nervous system development. Located in cortical microtubule and perinuclear region of cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; germline cell; larval muscle cell; mesoderm; and neurogenic region. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See alphaTub67C in Genome Data Viewer
Location:
67C4-67C4; 3-31 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9681268..9683370)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9674368..9676470)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene furry Neighboring gene CNMamide Receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphoribosyl pyrophosphate synthetase Neighboring gene antisense RNA:CR45804

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo RNA localization of I factor, a non-LTR retrotransposon, requires a cis-acting signal in ORF2 and ORF1 protein. Seleme MC, et al. Nucleic Acids Res, 2005. PMID 15687386, Free PMC Article
  2. In vivo analysis of MT-based vesicle transport by confocal reflection microscopy. Gáspár I, et al. Cell Motil Cytoskeleton, 2009 Feb. PMID 19130480
  3. Reorganization of the cytoskeleton during Drosophila oogenesis: implications for axis specification and intercellular transport. Theurkauf WE, et al. Development, 1992 Aug. PMID 1451668
  4. Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration. Cliffe A, et al. Nat Commun, 2017 Apr 4. PMID 28374738, Free PMC Article
  5. alpha4-Tubulin is involved in rapid formation of long microtubules to push apart the daughter centrosomes during earlyx Drosophila embryogenesis. Venkei Z, et al. J Cell Sci, 2006 Aug 1. PMID 16847053

See all (276) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alpha-Tubulin Regulates the Fate of Germline Stem Cells in Drosophila Testis.
    Title: α-Tubulin Regulates the Fate of Germline Stem Cells in Drosophila Testis.
  2. Glu426 is involved in stabilization of the microtubule-kinesin complexes when the kinesins are in the most labile, ADP-bound state.
    Title: Glu415 in the alpha-tubulins plays a key role in stabilizing the microtubule-ADP-kinesin complexes.
  3. Data show that alpha4-tubulin is enriched in the long microtubules that embrace the nuclear envelope and suggest that they push apart daughter centrosomes along the nuclear perimeter during the initial cleavage divisions.
    Title: alpha4-Tubulin is involved in rapid formation of long microtubules to push apart the daughter centrosomes during earlyx Drosophila embryogenesis.
  4. The Kavar(D) dominant female-sterile mutations reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.
    Title: The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female pronucleus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm aster formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
alpha-Tubulin at 67C
Names
CG8308-PA
alpha tubulin
alpha tubulin 67C
alpha-Tubulin
alpha4-tubulin
alphaT
alphaTub67C-PA
alphaTubulin 67C
alphaTubulin67C
alphatubulin
female sterile (3) kavar
kavar
tomaj
tubulin
tubulin at 67C
tubulin67C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9681268..9683370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079285.4 → NP_524009.2  alpha-Tubulin at 67C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524009.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06606, Q9VT30
    Related
    FBpp0076122
    Conserved Domains (1) summary
    cd02186
    Location:2 → 446
    alpha_tubulin; The alpha-tubulin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06606.1 P06606

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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