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CG42673 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39111, updated on 18-Sep-2024

Summary

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Official Symbol
CG42673provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0261555
Locus tag
Dmel_CG42673
See related
AllianceGenome:FB:FBgn0261555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE71517; BcDNA:RE71585; CG14178; CG17357; CG3179; CG32048; CG34272; Dmel\CG42673; Dm_3L:44995
Old locus tag
Dmel_CG32048; Dmel_CG34272
Summary
Predicted to enable nitric-oxide synthase binding activity. Predicted to be involved in postsynaptic actin cytoskeleton organization. Predicted to be located in glutamatergic synapse. Is expressed in several structures, including embryonic/larval gut; embryonic/larval nervous system; epithelial tube; extended germ band embryo; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG42673 in Genome Data Viewer
Location:
67B13-67C1; 3-31 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9547220..9596713)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9540320..9589813)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 67a Neighboring gene Ionotropic receptor 67a Neighboring gene antisense RNA:CR46246 Neighboring gene uncharacterized protein Neighboring gene Transmembrane channel-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection. Guzman RM, et al. Genetics, 2021 Mar 31. PMID 33789347, Free PMC Article
  2. Affinity Density: a novel genomic approach to the identification of transcription factor regulatory targets. Hazelett DJ, et al. Bioinformatics, 2009 Jul 1. PMID 19401399, Free PMC Article
  3. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Zhou S, et al. Environ Health Perspect, 2016 Jul. PMID 26859824, Free PMC Article
  4. Discovery of genes with highly restricted expression patterns in the Drosophila wing disc using DNA oligonucleotide microarrays. Butler MJ, et al. Development, 2003 Feb. PMID 12505997
  5. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nitric-oxide synthase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in postsynaptic actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in glutamatergic synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42673-PB
CG42673-PC
CG42673-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9547220..9596713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202149.2 → NP_001189078.1  uncharacterized protein Dmel_CG42673, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189078.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRS2
    Conserved Domains (1) summary
    cd01270
    Location:1 → 180
    PTB_CAPON-like; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) Phosphotyrosine-binding (PTB) domain

  2. NM_168352.2 → NP_729509.1  uncharacterized protein Dmel_CG42673, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729509.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SXX4, Q9VT10, Q9VT12
    Related
    FBpp0291849
    Conserved Domains (1) summary
    cd01270
    Location:1 → 180
    PTB_CAPON-like; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) Phosphotyrosine-binding (PTB) domain

  3. NM_168353.2 → NP_729510.1  uncharacterized protein Dmel_CG42673, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729510.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SXX4
    Related
    FBpp0291850
    Conserved Domains (1) summary
    cl17171
    Location:352 → 386
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MRS2 M9MRS2
Q8SXX4.1 Q8SXX4

Gene LinkOut

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