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PGRP-LF Peptidoglycan recognition protein LF [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39064, updated on 2-Nov-2024

Summary

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Official Symbol
PGRP-LFprovided by FlyBase
Official Full Name
Peptidoglycan recognition protein LFprovided by FlyBase
Primary source
FLYBASE:FBgn0035977
Locus tag
Dmel_CG4437
See related
AllianceGenome:FB:FBgn0035977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.581; CG4437; Dmel\CG4437; PGRP; pgrp-lf; PGRP-like; PGRPLF
Summary
Enables signaling receptor binding activity. Involved in several processes, including antibacterial humoral response; determination of adult lifespan; and negative regulation of peptidoglycan recognition protein signaling pathway. Located in plasma membrane. Is expressed in embryonic/larval fat body; embryonic/larval proventriculus; embryonic/larval salivary gland; epithelial tube; and imaginal disc. Orthologous to several human genes including PGLYRP3 (peptidoglycan recognition protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See PGRP-LF in Genome Data Viewer
Location:
67B1-67B1; 3-29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9349609..9351489)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9342709..9344589)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Peptidoglycan recognition protein LA Neighboring gene Peptidoglycan recognition protein LC Neighboring gene UDP-glucose pyrophosphorylase Neighboring gene uncharacterized protein Neighboring gene small VCP interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway. Basbous N, et al. EMBO Rep, 2011 Apr. PMID 21372849, Free PMC Article
  2. Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Seroude L, et al. Aging Cell, 2002 Oct. PMID 12882353
  3. Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE. Neyen C, et al. J Immunol, 2012 Aug 15. PMID 22772451
  4. Bacteria sensing mechanisms in Drosophila gut: Local and systemic consequences. Capo F, et al. Dev Comp Immunol, 2016 Nov. PMID 26778296
  5. Functional diversity of the Drosophila PGRP-LC gene cluster in the response to lipopolysaccharide and peptidoglycan. Werner T, et al. J Biol Chem, 2003 Jul 18. PMID 12777387

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Negative regulation of NF-kappaB/IMD pathway by PGRP-LF is crucial to ensure proper induction of apoptosis and consequently normal fly development.
    Title: Inhibition of a NF-κB/Diap1 Pathway by PGRP-LF Is Required for Proper Apoptosis during Drosophila Development.
  2. Data show that the Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.
    Title: The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.
  3. By genetically interacting with PGRP-LC, PGRP-LF prevents constitutive activation of both the JNK and the immune deficiency pathways in the absence of infection.
    Title: The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation.
  4. membrane bound and has its two PGRP domains, z and w, localized outside the cell
    Title: Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables N-acetylmuramoyl-L-alanine amidase activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial humoral response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to other organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in peptidoglycan catabolic process IKR
Inferred from Key Residues
more info
 PubMed 
involved_in response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peptidoglycan recognition protein LF
Names
CG4437-PA
PGRP-LF-PA
PRGP-like
Peptidoglycan-recognition protein-LF
peptidoglycan recognition protein
peptidoglycan recognition protein-LF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9349609..9351489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140042.3 → NP_648299.3  peptidoglycan recognition protein LF [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648299.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SXQ7, Q9VSW0
    Related
    FBpp0076167
    Conserved Domains (2) summary
    smart00701
    Location:57 → 199
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
    cl02712
    Location:236 → 363
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXQ7.1 Q8SXQ7

Gene LinkOut

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