Rdl Resistant to dieldrin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rdlprovided by FlyBase
Official Full Name: Resistant to dieldrinprovided by FlyBase
Primary source: FLYBASE:FBgn0004244
Locus tag: Dmel_CG10537
See related: AllianceGenome:FB:FBgn0004244
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10537; CT29555; DGABAAR; Dmel\CG10537; DmRdl; DmRDL; gaba; GABA; GABA-R; GABAAR; GABAr; GABAR; GABA[[A]]; GABA[[A]] receptor; GABA[[A]]-R; GABA[[A]]R; LCCH1; Rd1; rdl; RDL
Summary: Enables GABA-gated chloride ion channel activity. Involved in several processes, including inter-male aggressive behavior; olfactory behavior; and regulation of olfactory learning. Located in several cellular components, including dendrite; neuron projection membrane; and neuronal cell body membrane. Is expressed in adult head; adult peptidergic neurons; adult ventral nerve cord; and muscle cell. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1) and GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 67A1-67A1; 3-28 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9145838..9182149, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9138938..9175249, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABA-gated chloride channel mutation (Rdl) induces cholinergic physiological compensation resulting in cross resistance in Drosophila melanogaster.
Title: GABA-gated chloride channel mutation (Rdl) induces cholinergic physiological compensation resulting in cross resistance in Drosophila melanogaster.
Important amino acids for function of the insect Rdl GABA receptor.
Title: Important amino acids for function of the insect Rdl GABA receptor.
A unique primary structure of RDL (resistant to dieldrin) confers resistance to GABA-gated chloride channel blockers in the two-spotted spider mite Tetranychus urticae Koch.
Title: A unique primary structure of RDL (resistant to dieldrin) confers resistance to GABA-gated chloride channel blockers in the two-spotted spider mite Tetranychus urticae Koch.
Results indicate that the ability of faf, hiw or Rdl to modulate sleep and protect against cognitive impairments during waking is circuit dependent. Decreasing hiw and Rdl within the Mushroom Bodies protects against the negative effects of sleep deprivation as indicated by the absence of a subsequent homeostatic response, or deficits in short-term memory.
Title: Identification of Genes that Maintain Behavioral and Structural Plasticity during Sleep Loss.
overexpression of Rdl GABAARs in the motoneuron caused an increase in dendritic length and branch numbers in the distal GABAergic domain that came at the cost of a reduced arbor in the proximal cholinergic domain.
Title: Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material.
point mutations at the Rdl (Ala)301 site provide moderate resistance to phenylpyrazoles in D. melanogaster
Title: The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster.
Data indicate that duplication of the Rdl target site creates permanent heterozygosity, providing unique potential for adaptive mutations to accrue in one copy, without abolishing the endogenous role of an essential gene.
Title: Gene duplication in the major insecticide target site, Rdl, in Drosophila melanogaster.
insulin-like peptides express the metabotropic GABA(B) receptor (GBR), but not the ionotropic GABA(A) receptor subunit RDL
Title: Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila.
model of the insect GABA receptor binding site and the location of agonists within it
Title: Molecular characterization of agonists that bind to an insect GABA receptor.
Data show that RNA interference-mediated knockdown of the GABA(A) receptor gene, Resistant to dieldrin (Rdl), in PDF neurons reduces sleep, consistent with a role for GABA in inhibiting PDF neuron function.
Title: The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0929 (e-PCR)
- UniSTS:75586

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-A receptor activity	TAS Traceable Author Statement more info	PubMed
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mechanical stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: resistant to dieldrin

Names: CG10537-PA; CG10537-PC; CG10537-PD; CG10537-PE; CG10537-PF; CG10537-PG; GABA A beta-subunit; GABA receptor; GABA[[A]] receptor; Rdl GABA[[A]] receptor; Rdl-PA; Rdl-PC; Rdl-PD; Rdl-PE; Rdl-PF; Rdl-PG; resistance to DieLdrin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9145838..9182149 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274686.1 → NP_001261615.1 resistant to dieldrin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261615.1

Status: REVIEWED

UniProtKB/TrEMBL

F2FB52, M9PEV8

Conserved Domains (2) summary

cd19008
Location:83 → 266

LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

pfam02932
Location:274 → 586

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_168321.3 → NP_729461.1 resistant to dieldrin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729461.1

Status: REVIEWED

UniProtKB/TrEMBL

V9ZAE2

Related

FBpp0076263

Conserved Domains (2) summary

cd19008
Location:83 → 266

LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

pfam02932
Location:274 → 586

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001274687.1 → NP_001261616.1 resistant to dieldrin, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261616.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25123, P92138, Q24561, Q26302, Q7JPX8, Q8IQB5, Q8IQB6, Q961R4, Q9TX51, Q9VSV0

UniProtKB/TrEMBL

F2FB52, M9PHV2

Conserved Domains (2) summary

cd19008
Location:83 → 266

LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

pfam02932
Location:274 → 586

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001274688.1 → NP_001261617.1 resistant to dieldrin, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261617.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBZ1, V9ZAE2

Conserved Domains (2) summary

cd19008
Location:83 → 266

LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

pfam02932
Location:274 → 588

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_079267.4 → NP_523991.2 resistant to dieldrin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523991.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P25123, P92138, Q24561, Q26302, Q7JPX8, Q8IQB5, Q8IQB6, Q961R4, Q9TX51, Q9VSV0

UniProtKB/TrEMBL

F2FB52, M9PHV2

Related

FBpp0076261

Conserved Domains (2) summary

cd19008
Location:83 → 266

LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

pfam02932
Location:274 → 586

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_168322.3 → NP_729462.2 resistant to dieldrin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729462.2

Status: REVIEWED

UniProtKB/TrEMBL

V9ZAE2

Conserved Domains (2) summary

TIGR00860
Location:61 → 562

LIC; Cation transporter family protein

cd19008
Location:83 → 266

LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)