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teq Tequila [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39048, updated on 2-Nov-2024

Summary

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Official Symbol
teqprovided by FlyBase
Official Full Name
Tequilaprovided by FlyBase
Primary source
FLYBASE:FBgn0023479
Locus tag
Dmel_CG4821
See related
AllianceGenome:FB:FBgn0023479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:ParkEST161; BEST:CK00198; BEST:GH18038; CG18153; CG18403; CG4821; CG4948; CK00198; Dmel\CG4821; graal; SP72; Teq
Summary
Predicted to enable serine-type endopeptidase activity. Involved in glucose homeostasis; memory; and positive regulation of insulin secretion. Predicted to be located in extracellular region and membrane. Is expressed in adult brain; adult head; eye; and neuron of the dorsal anterior lateral group of the protocerebrum. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 1 and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See teq in Genome Data Viewer
Location:
66F4-66F5; 3-28 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9074643..9092131)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9067743..9085231)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comment on "Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila". Sonderegger P, et al. Science, 2007 Jun 22. PMID 17588915
  2. Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains. Bikker FJ, et al. J Biol Chem, 2004 Nov 12. PMID 15355985
  3. Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila. Didelot G, et al. Science, 2006 Aug 11. PMID 16902143
  4. Parametric and genetic analysis of Drosophila appetitive long-term memory and sugar motivation. Colomb J, et al. Genes Brain Behav, 2009 Jun. PMID 19220480
  5. To favor survival under food shortage, the brain disables costly memory. Plaçais PY, et al. Science, 2013 Jan 25. PMID 23349289

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 9076982-9084484 mobile_element_type = transposon:412{}teq[iso-1]

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in short-term memory IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tequila
Names
CG4821-PC
CG4821-PD
CG4821-PF
CG4821-PG
teq-PC
teq-PD
teq-PF
teq-PG
NP_001163393.2
  • unusual splice
NP_648288.2
  • unusual splice
NP_729451.1
NP_729452.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9074643..9092131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140031.3 → NP_648288.2  tequila, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648288.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960G6, Q9VSU1, Q9VSU2
    Conserved Domains (9) summary
    smart00192
    Location:2337 → 2370
    LDLa; Low-density lipoprotein receptor domain class A
    smart00020
    Location:2546 → 2781
    Tryp_SPc; Trypsin-like serine protease
    smart00202
    Location:2382 → 2480
    SR; Scavenger receptor Cys-rich
    smart00494
    Location:136 → 184
    ChtBD2; Chitin-binding domain type 2
    cd00112
    Location:2193 → 2222
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:2547 → 2784
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:2386 → 2480
    SRCR; Scavenger receptor cysteine-rich domain
    pfam01607
    Location:65 → 115
    CBM_14; Chitin binding Peritrophin-A domain
    cl23782
    Location:1051 → 1126
    RCR; Chitin synthesis regulation, resistance to Congo red

  2. NM_001169922.3 → NP_001163393.2  tequila, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163393.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JI93, Q9BI19
    Conserved Domains (9) summary
    smart00192
    Location:1924 → 1957
    LDLa; Low-density lipoprotein receptor domain class A
    smart00020
    Location:2133 → 2368
    Tryp_SPc; Trypsin-like serine protease
    smart00202
    Location:1969 → 2067
    SR; Scavenger receptor Cys-rich
    smart00494
    Location:136 → 184
    ChtBD2; Chitin-binding domain type 2
    cd00112
    Location:1780 → 1809
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:2134 → 2371
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:1973 → 2067
    SRCR; Scavenger receptor cysteine-rich domain
    pfam01607
    Location:65 → 115
    CBM_14; Chitin binding Peritrophin-A domain
    cl23782
    Location:1038 → 1126
    RCR; Chitin synthesis regulation, resistance to Congo red

  3. NM_168314.3 → NP_729451.1  tequila, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729451.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQB8, Q9U1I2
    Related
    FBpp0076252
    Conserved Domains (8) summary
    smart00192
    Location:995 → 1028
    LDLa; Low-density lipoprotein receptor domain class A
    smart00020
    Location:1204 → 1439
    Tryp_SPc; Trypsin-like serine protease
    smart00202
    Location:1040 → 1138
    SR; Scavenger receptor Cys-rich
    smart00494
    Location:136 → 184
    ChtBD2; Chitin-binding domain type 2
    cd00112
    Location:851 → 880
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:1205 → 1442
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:1044 → 1138
    SRCR; Scavenger receptor cysteine-rich domain
    pfam01607
    Location:65 → 115
    CBM_14; Chitin binding Peritrophin-A domain

  4. NM_168315.3 → NP_729452.1  tequila, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729452.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TPA5, Q9VST9
    Related
    FBpp0076254
    Conserved Domains (2) summary
    smart00494
    Location:136 → 184
    ChtBD2; Chitin-binding domain type 2
    pfam01607
    Location:65 → 115
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JI93 E1JI93
O45029 O45029
Q8IQB8 Q8IQB8
Q8MRY3 Q8MRY3
Q8T0I5 Q8T0I5
Q960G6 Q960G6
Q9BI19 Q9BI19
Q9U1I2 Q9U1I2
Q9U1I3 Q9U1I3
Q9VST9 Q9VST9
Q9VSU2 Q9VSU2

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