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OR8B3 olfactory receptor family 8 subfamily B member 3 [ Homo sapiens (human) ]

Gene ID: 390271, updated on 2-Nov-2024

Summary

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Official Symbol
OR8B3provided by HGNC
Official Full Name
olfactory receptor family 8 subfamily B member 3provided by HGNC
Primary source
HGNC:HGNC:8472
See related
Ensembl:ENSG00000284609 AllianceGenome:HGNC:8472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-311
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See OR8B3 in Genome Data Viewer
Location:
11q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124395534..124409807, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124424199..124438480, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124265430..124268920, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily B member 1 pseudogene Neighboring gene olfactory receptor family 8 subfamily C member 1 pseudogene Neighboring gene olfactory receptor family 8 subfamily B member 2 Neighboring gene uncharacterized LOC107984404 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:124275254-124276453 Neighboring gene olfactory receptor family 8 subfamily X member 1 pseudogene Neighboring gene olfactory receptor family 8 subfamily B member 4 Neighboring gene olfactory receptor family 8 subfamily B member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
olfactory receptor 8B3
Names
olfactory receptor OR11-311

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005467.2 → NP_001005467.1  olfactory receptor 8B3

    See identical proteins and their annotated locations for NP_001005467.1

    Status: VALIDATED

    Source sequence(s)
    AP001804
    Consensus CDS
    CCDS31709.1
    UniProtKB/Swiss-Prot
    Q6IFQ8, Q8NGG8, Q8NGH1
    UniProtKB/TrEMBL
    A0A126GWT8
    Related
    ENSP00000493120.1, ENST00000641139.1
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 289
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31 → 304
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    124395534..124409807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017716.2 → XP_016873205.1  olfactory receptor 8B3 isoform X1

    UniProtKB/Swiss-Prot
    Q6IFQ8, Q8NGG8, Q8NGH1
    UniProtKB/TrEMBL
    A0A126GWT8
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 289
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31 → 304
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    124424199..124438480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368743.1 → XP_054224718.1  olfactory receptor 8B3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGG8.3 GenPept UniProtKB/Swiss-Prot:Q8NGG8

Gene LinkOut

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