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SPACA5 sperm acrosome associated 5 [ Homo sapiens (human) ]

Gene ID: 389852, updated on 5-Mar-2024

Summary

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Official Symbol
SPACA5provided by HGNC
Official Full Name
sperm acrosome associated 5provided by HGNC
Primary source
HGNC:HGNC:31353
See related
Ensembl:ENSG00000171489 MIM:300593; AllianceGenome:HGNC:31353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYC5; LYZL5; SLLP2; SLLP-X; UNQ6288; PNPK6288
Summary
Predicted to enable lysozyme activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 3.7) See more
Orthologs
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Genomic context

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Location:
Xp11.23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (48004336..48009733)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (47414513..47419909)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47863734..47869130)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 57 Neighboring gene zinc finger protein 81 Neighboring gene CRISPRi-FlowFISH-validated HDAC6 regulatory element 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29599 Neighboring gene zinc finger protein 182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20813 Neighboring gene ZNF630 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:47931149-47931345 Neighboring gene small nucleolar RNA U13 Neighboring gene zinc finger protein 630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. Chen YT, et al. Genes Chromosomes Cancer, 2006 Apr. PMID 16382448
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sperm acrosome-associated protein 5
Names
lysozyme-like protein 5
sperm lysozyme-like protein 2
sperm-specific lysozyme-like protein X
testicular tissue protein Li 113
NP_001381227.1
NP_995328.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394298.1 → NP_001381227.1  sperm acrosome-associated protein 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC244636
    Consensus CDS
    CCDS14286.1
    UniProtKB/Swiss-Prot
    Q6UWD1, Q96QH8
    UniProtKB/TrEMBL
    A0A140VJN7
    Related
    ENSP00000366139.3, ENST00000376940.4
    Conserved Domains (1) summary
    cd16897
    Location:22 → 147
    LYZ_C; C-type lysozyme

  2. NM_205856.3 → NP_995328.2  sperm acrosome-associated protein 5 precursor

    See identical proteins and their annotated locations for NP_995328.2

    Status: VALIDATED

    Source sequence(s)
    AC244636
    Consensus CDS
    CCDS14286.1
    UniProtKB/Swiss-Prot
    Q6UWD1, Q96QH8
    UniProtKB/TrEMBL
    A0A140VJN7
    Related
    ENSP00000305847.5, ENST00000304355.9
    Conserved Domains (1) summary
    cd16897
    Location:22 → 147
    LYZ_C; C-type lysozyme

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    48004336..48009733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    47414513..47419909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96QH8.1 GenPept UniProtKB/Swiss-Prot:Q96QH8

Gene LinkOut

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