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MROH5 maestro heat like repeat family member 5 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 389690, updated on 5-Mar-2024

Summary

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Official Symbol
MROH5provided by HGNC
Official Full Name
maestro heat like repeat family member 5 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:42976
See related
Ensembl:ENSG00000226807 AllianceGenome:HGNC:42976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Annotation information
Annotation category: suggests misassembly
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Biased expression in testis (RPKM 3.5) and heart (RPKM 0.2) See more
Orthologs
mouse all
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Genomic context

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Location:
8q24.3
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141433825..141507229, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142561183..142635781, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142443925..142517329, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142385104-142385878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142385879-142386654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142386655-142387429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142394223-142394840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142401193-142401813 Neighboring gene antisense transcript of PTP4A3, liver carcinoma survival associated Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142413010-142413773 Neighboring gene protein tyrosine phosphatase 4A3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:142417407-142417907 Neighboring gene VISTA enhancer hs1882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142441707-142442687 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142443451-142444139 Neighboring gene Putative chemokine-related protein FP248 Neighboring gene uncharacterized LOC105375789 Neighboring gene small nucleolar RNA SNORD5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1pseudogene 38 Neighboring gene CEB42 minisatellite repeat instability region Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142501938-142502812 Neighboring gene uncharacterized LOC124902031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142517660-142518180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19593 Neighboring gene uncharacterized LOC105375791

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetics of coronary artery calcification among African Americans, a meta-analysis. Wojczynski MK, et al. BMC Med Genet, 2013 Jul 19. PMID 23870195, Free PMC Article
  2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  3. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of coronary artery calcification among African Americans, a meta-analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of FLJ43860 protein by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43860

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
maestro heat-like repeat family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207414.3 → NP_997297.2  maestro heat-like repeat family member 5

    See identical proteins and their annotated locations for NP_997297.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) differs at a polymorphic nucleotide compared to the reference genome sequence and represents the protein coding allele.
    Source sequence(s)
    ABBA01013690, AC100803, AC138647, KF459654, KF459918
    UniProtKB/Swiss-Prot
    Q6ZUA9

RNA

  1. NR_102363.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two internal exons and uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100803, AC138647, BC144560, KF459654, KF459918
    Related
    ENST00000521053.5

  2. NR_102364.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks four internal exons but it includes one additional exon, and it uses three alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100803, AC138647, BC144560, KF459654, KF459918
    Related
    ENST00000523857.5

  3. NR_160399.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) contains a polymorphic nt that creates an early termination codon compared to variant 1, coding. The resulting transcript is considered to be non-protein coding since it is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100803, AC138647, KF459654, KF459918
    Related
    ENST00000430863.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    141433825..141507229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791786.1 Reference GRCh38.p14 PATCHES

    Range
    100379..173783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187574.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    106281..123607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    142561183..142635781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZUA9.2 GenPept UniProtKB/Swiss-Prot:Q6ZUA9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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