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Sbp2 SECIS-binding protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38934, updated on 11-Sep-2024

Summary

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Official Symbol
Sbp2provided by FlyBase
Official Full Name
SECIS-binding protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0087039
Locus tag
Dmel_CG7066
See related
AllianceGenome:FB:FBgn0087039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7066; Dmel\CG7066; SBP2
Summary
Enables RNA stem-loop binding activity and selenocysteine insertion sequence binding activity. Involved in selenocysteine incorporation. Part of ribonucleoprotein complex. Orthologous to several human genes including SECISBP2 (SECIS binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Sbp2 in Genome Data Viewer
Location:
66C5-66C5; 3-24 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8304157..8305325)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8297257..8298425)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 66a Neighboring gene Bax Inhibitor-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A short motif in Drosophila SECIS Binding Protein 2 provides differential binding affinity to SECIS RNA hairpins. Takeuchi A, et al. Nucleic Acids Res, 2009 Apr. PMID 19223320, Free PMC Article
  2. A taste receptor required for the caffeine response in vivo. Moon SJ, et al. Curr Biol, 2006 Sep 19. PMID 16979558
  3. Selenoproteins: molecular pathways and physiological roles. Labunskyy VM, et al. Physiol Rev, 2014 Jul. PMID 24987004, Free PMC Article
  4. A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila. Hirosawa-Takamori M, et al. FASEB J, 2009 Jan. PMID 18772345, Free PMC Article
  5. Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Lobanov AV, et al. Protein Sci, 2008 Jan. PMID 18156471, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA stem-loop binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables selenocysteine insertion sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables selenocysteine insertion sequence binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in selenocysteine incorporation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SECIS-binding protein 2
Names
CG7066-PA
SECIS binding protein 2
SECIS-binding protein2
Sbp2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8304157..8305325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139947.3 → NP_648204.1  SECIS-binding protein 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZV6, Q9VSH1
    Related
    FBpp0076430
    Conserved Domains (1) summary
    pfam01248
    Location:200 → 290
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSH1 Q9VSH1

Gene LinkOut

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