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LRRC14B leucine rich repeat containing 14B [ Homo sapiens (human) ]

Gene ID: 389257, updated on 5-Mar-2024

Summary

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Official Symbol
LRRC14Bprovided by HGNC
Official Full Name
leucine rich repeat containing 14Bprovided by HGNC
Primary source
HGNC:HGNC:37268
See related
Ensembl:ENSG00000185028 AllianceGenome:HGNC:37268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a leucine-rich repeat containing protein that is a member of the PRAME family. [provided by RefSeq, Apr 2017]
Expression
Biased expression in heart (RPKM 5.9) and prostate (RPKM 0.8) See more
Orthologs
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Genomic context

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See LRRC14B in Genome Data Viewer
Location:
5p15.33
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (191495..196334)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (182851..187790)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (191610..196449)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72025-72555 Neighboring gene Spi-C transcription factor pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:77366-78265 Neighboring gene Sharpr-MPRA regulatory region 259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:90483-91322 Neighboring gene NANOG hESC enhancer GRCh37_chr5:99879-100414 Neighboring gene pleckstrin homology and RhoGEF domain containing G4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137535-138040 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159786-160286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:160287-160787 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:169157-170356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170845-171358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:171359-171872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:181876-182376 Neighboring gene Sharpr-MPRA regulatory region 15179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22268 Neighboring gene Sharpr-MPRA regulatory region 11960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22270 Neighboring gene uncharacterized LOC124900929 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:207882-208207 Neighboring gene coiled-coil domain containing 127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:218445-219253 Neighboring gene succinate dehydrogenase complex flavoprotein subunit A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Seo G, et al. Cell Rep, 2020 Jul 7. PMID 32640226, Free PMC Article
  2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 14B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053103.1 RefSeqGene

    Range
    4985..9824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080478.3 → NP_001073947.1  leucine-rich repeat-containing protein 14B

    See identical proteins and their annotated locations for NP_001073947.1

    Status: REVIEWED

    Source sequence(s)
    AC021087
    Consensus CDS
    CCDS47184.1
    UniProtKB/Swiss-Prot
    A6NHZ5
    Related
    ENSP00000327675.3, ENST00000328278.4
    Conserved Domains (3) summary
    cd00116
    Location:264 → 419
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:306 → 332
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:281 → 304
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    191495..196334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    182851..187790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NHZ5.3 GenPept UniProtKB/Swiss-Prot:A6NHZ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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