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CD164L2 CD164 molecule like 2 [ Homo sapiens (human) ]

Gene ID: 388611, updated on 5-Mar-2024

Summary

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Official Symbol
CD164L2provided by HGNC
Official Full Name
CD164 molecule like 2provided by HGNC
Primary source
HGNC:HGNC:32043
See related
Ensembl:ENSG00000174950 AllianceGenome:HGNC:32043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ6122; EAPG6122
Summary
Predicted to be integral component of membrane. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 3.1), esophagus (RPKM 2.8) and 5 other tissues See more
Orthologs
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Genomic context

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See CD164L2 in Genome Data Viewer
Location:
1p36.11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (27379176..27383333, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27220481..27224643, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27705666..27709823, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27685945-27686480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27686481-27687016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27692433-27693376 Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27693377-27694318 Neighboring gene ficolin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27717742-27718278 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27718279-27718815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27719353-27719888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27720717-27721514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27725651-27726603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 548 Neighboring gene Sharpr-MPRA regulatory region 8314 Neighboring gene G protein-coupled receptor 3 Neighboring gene WASP family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 549 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27756559-27757532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population. Lu J, et al. Clin Exp Hypertens, 2012. PMID 22471352
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Found that a common variant of FCN3/CD164L2 is associated with hypertension in Chinese population.
    Title: A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD164 sialomucin-like 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330448.1 → NP_001317377.1  CD164 sialomucin-like 2 protein isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    FO393419
    Consensus CDS
    CCDS81287.1
    UniProtKB/Swiss-Prot
    B2RPJ0, Q5JXD6, Q6UWJ8
    Related
    ENSP00000363142.1, ENST00000374030.3
    Conserved Domains (1) summary
    pfam05283
    Location:54 → 173
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

  2. NM_207397.5 → NP_997280.2  CD164 sialomucin-like 2 protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_997280.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron in the 3' end compared to variant 1. The resulting isoform (2) is 1 aa shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AY358761, DB114521, FO393419
    Consensus CDS
    CCDS302.1
    UniProtKB/Swiss-Prot
    Q6UWJ8
    Related
    ENSP00000363139.3, ENST00000374027.7
    Conserved Domains (1) summary
    pfam05283
    Location:54 → 173
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    27379176..27383333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541441.2 → XP_011539743.1  CD164 sialomucin-like 2 protein isoform X1

    See identical proteins and their annotated locations for XP_011539743.1

    Conserved Domains (1) summary
    pfam05283
    Location:54 → 173
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

RNA

  1. XR_241190.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    27220481..27224643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336508.1 → XP_054192483.1  CD164 sialomucin-like 2 protein isoform X1

RNA

  1. XR_008486043.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UWJ8.3 GenPept UniProtKB/Swiss-Prot:Q6UWJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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