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ZNF761 zinc finger protein 761 [ Homo sapiens (human) ]

Gene ID: 388561, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF761provided by HGNC
Official Full Name
zinc finger protein 761provided by HGNC
Primary source
HGNC:HGNC:23179
See related
Ensembl:ENSG00000160336 AllianceGenome:HGNC:23179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF468
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in prostate (RPKM 24.8), placenta (RPKM 5.8) and 20 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53431984..53458261)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56511539..56537815)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53935237..53961515)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene zinc finger protein 765 Neighboring gene ribosomal protein L39 pseudogene 36 Neighboring gene vomeronasal 1 receptor 101 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11010 Neighboring gene tropomyosin 3 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 10215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53971207-53971768 Neighboring gene vomeronasal 1 receptor 102 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53971769-53972331 Neighboring gene zinc finger protein 813 Neighboring gene tropomyosin 3 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole genome screen for HIV restriction factors. Liu L, et al. Retrovirology, 2011 Nov 14. PMID 22082156, Free PMC Article
  2. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 761 (ZNF761) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF765-ZNF761

Readthrough gene: ZNF765-ZNF761, Included gene: ZNF765, Included gene: ZNF525

Homology

Clone Names

  • FLJ16231, FLJ35333, KIAA2033, MGC87789

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 761
Names
zinc finger protein 468

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008401.4 → NP_001008401.3  zinc finger protein 761 isoform a

    See identical proteins and their annotated locations for NP_001008401.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode the same isoform.
    Source sequence(s)
    AB107355, AC022137, BM977910, DA237674
    UniProtKB/Swiss-Prot
    A0A087WXT7, Q6ZNB9, Q86XN6
    Conserved Domains (4) summary
    COG5048
    Location:242 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:651 → 737
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  2. NM_001289951.2 → NP_001276880.1  zinc finger protein 761 isoform a

    See identical proteins and their annotated locations for NP_001276880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
    Source sequence(s)
    AC022137, BM977910, DA237674, DB232487
    UniProtKB/Swiss-Prot
    A0A087WXT7, Q6ZNB9, Q86XN6
    Related
    ENSP00000507666.1, ENST00000684525.1
    Conserved Domains (4) summary
    COG5048
    Location:242 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:651 → 737
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  3. NM_001289952.1 → NP_001276881.1  zinc finger protein 761 isoform a

    See identical proteins and their annotated locations for NP_001276881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
    Source sequence(s)
    AB107355, AC022137, BM977910, DB232487
    UniProtKB/Swiss-Prot
    A0A087WXT7, Q6ZNB9, Q86XN6
    Related
    ENSP00000480218.1, ENST00000432094.6
    Conserved Domains (4) summary
    COG5048
    Location:242 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:651 → 737
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  4. NM_001289953.1 → NP_001276882.1  zinc finger protein 761 isoform b

    See identical proteins and their annotated locations for NP_001276882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs, and contains an alternate 3' terminal exon and thus differs in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    BC071639, BC103708, DB232487
    Consensus CDS
    CCDS77353.1
    UniProtKB/TrEMBL
    Q6IQ01
    Related
    ENSP00000481271.1, ENST00000613950.1
    Conserved Domains (2) summary
    smart00349
    Location:8 → 50
    KRAB; krueppel associated box
    pfam01352
    Location:8 → 47
    KRAB; KRAB box

RNA

  1. NR_110551.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, and contains an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC071639, BC103708, DA237674, DB232487
    Related
    ENST00000610928.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53431984..53458261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56511539..56537815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86XN6.3 GenPept UniProtKB/Swiss-Prot:Q86XN6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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