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POTEC POTE ankyrin domain family member C [ Homo sapiens (human) ]

Gene ID: 388468, updated on 17-Sep-2024

Summary

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Official Symbol
POTECprovided by HGNC
Official Full Name
POTE ankyrin domain family member Cprovided by HGNC
Primary source
HGNC:HGNC:33894
See related
Ensembl:ENSG00000183206 AllianceGenome:HGNC:33894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A26B2; POTE18; CT104.6; POTE-18
Expression
Restricted expression toward testis (RPKM 4.1) See more
Orthologs
all
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Genomic context

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See POTEC in Genome Data Viewer
Location:
18p11.21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (14507339..14543600, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (14670242..14706527, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (14507338..14543599, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr18:14458017-14458177 Neighboring gene LONRF2 pseudogene 1 Neighboring gene CXADR pseudogene 3 Neighboring gene GRAM domain containing 4 pseudogene 7 Neighboring gene RNA, U6 small nuclear 1021, pseudogene Neighboring gene uncharacterized LOC105372004 Neighboring gene olfactory receptor family 4 subfamily K member 7 pseudogene Neighboring gene olfactory receptor family 4 subfamily K member 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. Bera TK, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12475935, Free PMC Article
  2. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • DKFZp686J0529

General protein information

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Preferred Names
POTE ankyrin domain family member C
Names
ANKRD26-like family B member 2
cancer/testis antigen family 104, member 6
prostate, ovary, testis-expressed protein on chromosome 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137671.2 → NP_001131143.1  POTE ankyrin domain family member C isoform 1

    See identical proteins and their annotated locations for NP_001131143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AP006261
    Consensus CDS
    CCDS45835.1
    UniProtKB/Swiss-Prot
    B2RU33
    UniProtKB/TrEMBL
    A0A087X187
    Related
    ENSP00000351856.5, ENST00000358970.10
    Conserved Domains (3) summary
    PHA03095
    Location:222 → 349
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:238 → 269
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:143 → 236
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. NR_134878.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK307658, AP006261, BX649118
    Related
    ENST00000511306.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    14507339..14543600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    14670242..14706527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RU33.2 GenPept UniProtKB/Swiss-Prot:B2RU33

Gene LinkOut

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