U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

INSYN1 inhibitory synaptic factor 1 [ Homo sapiens (human) ]

Gene ID: 388135, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
INSYN1provided by HGNC
Official Full Name
inhibitory synaptic factor 1provided by HGNC
Primary source
HGNC:HGNC:33753
See related
Ensembl:ENSG00000205363 MIM:617128; AllianceGenome:HGNC:33753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C15orf59
Summary
Predicted to be involved in inhibitory postsynaptic potential. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 6.6), heart (RPKM 2.3) and 12 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See INSYN1 in Genome Data Viewer
Location:
15q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (73735458..73753351, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (71552818..71570722, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74027799..74045692, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:73975613-73976121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6638 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:73977139-73977645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:73988434-73988945 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr15:73988946-73989458 and GRCh37_chr15:73989459-73989969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6639 Neighboring gene CD276 molecule Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:73994347-73995068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74043809-74044582 Neighboring gene INSYN1 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:74066905-74068104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74089589-74090547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74091135-74091814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74091815-74092493 Neighboring gene uncharacterized LOC105370892

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Open reading frames associated with cancer in the dark matter of the human genome. Delgado AP, et al. Cancer Genomics Proteomics, 2014 Jul-Aug. PMID 25048349
  2. Identification of an elaborate complex mediating postsynaptic inhibition. Uezu A, et al. Science, 2016 Sep 9. PMID 27609886, Free PMC Article
  3. Protein phosphatase 1γ isoforms linked interactions in the brain. Esteves SL, et al. J Mol Neurosci, 2013 May. PMID 23080069
  4. Identification of the human testis protein phosphatase 1 interactome. Fardilha M, et al. Biochem Pharmacol, 2011 Nov 15. PMID 21382349
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC131524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in inhibitory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
inhibitory synaptic factor 1
Names
UPF0583 protein C15orf59
inhibitory synaptic protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039614.3 → NP_001034703.1  inhibitory synaptic factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001034703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC022188
    Consensus CDS
    CCDS32289.1
    UniProtKB/Swiss-Prot
    Q2T9L4
    Related
    ENSP00000457205.1, ENST00000569673.3
    Conserved Domains (1) summary
    pfam15252
    Location:52 → 280
    DUF4589; Domain of unknown function (DUF4589)

  2. NM_001303254.2 → NP_001290183.1  inhibitory synaptic factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC022188
    Conserved Domains (1) summary
    pfam15252
    Location:24 → 252
    DUF4589; Domain of unknown function (DUF4589)

  3. NM_001384351.1 → NP_001371280.1  inhibitory synaptic factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022188
    Consensus CDS
    CCDS32289.1
    UniProtKB/Swiss-Prot
    Q2T9L4
    Conserved Domains (1) summary
    pfam15252
    Location:52 → 280
    DUF4589; Domain of unknown function (DUF4589)

  4. NM_001384352.1 → NP_001371281.1  inhibitory synaptic factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022188
    Conserved Domains (1) summary
    pfam15252
    Location:1 → 139
    DUF4589; Domain of unknown function (DUF4589)

  5. NM_001384353.1 → NP_001371282.1  inhibitory synaptic factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022188
    Conserved Domains (1) summary
    pfam15252
    Location:1 → 139
    DUF4589; Domain of unknown function (DUF4589)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    73735458..73753351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432489.1 → XP_047288445.1  inhibitory synaptic factor 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    71552818..71570722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377894.1 → XP_054233869.1  inhibitory synaptic factor 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2T9L4.1 GenPept UniProtKB/Swiss-Prot:Q2T9L4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous