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Cln7 Cln7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38813, updated on 2-Nov-2024

Summary

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Official Symbol
Cln7provided by FlyBase
Official Full Name
Cln7provided by FlyBase
Primary source
FLYBASE:FBgn0035767
Locus tag
Dmel_CG8596
See related
AllianceGenome:FB:FBgn0035767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8596; cln7; CLN7; Dmel\CG8596
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in postsynaptic density membrane. Is expressed in adult head; plasmatocyte primordium; and ventral epidermis primordium. Used to study neuronal ceroid lipofuscinosis 7. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Cln7 in Genome Data Viewer
Location:
65F5-65F5; 3-20 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7341884..7345183, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7334984..7338283, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene wurmchen 1 Neighboring gene wurmchen 2 Neighboring gene Establishment of cohesion Neighboring gene lark Neighboring gene uncharacterized protein Neighboring gene Signal recognition particle 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. in vivo localization of the neuronal ceroid lipofuscinosis proteins, CLN3 and CLN7, at endogenous expression levels. Mohammed A, et al. Neurobiol Dis, 2017 Jul. PMID 28365214, Free PMC Article
  2. Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease. Jones MA, et al. Biol Open, 2014 Apr 4. PMID 24705017, Free PMC Article
  3. The neuronal ceroid lipofuscinosis protein Cln7 functions in the postsynaptic cell to regulate synapse development. Connolly KJ, et al. Sci Rep, 2019 Oct 30. PMID 31666534, Free PMC Article
  4. Glucose Availability Alters Gene and Protein Expression of Several Newly Classified and Putative Solute Carriers in Mice Cortex Cell Culture and D. melanogaster. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 32733888, Free PMC Article
  5. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLN7 (and CLN3) are predominantly expressed in the glia that form the insect blood-brain-barrier.
    Title: in vivo localization of the neuronal ceroid lipofuscinosis proteins, CLN3 and CLN7, at endogenous expression levels.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Cln7
Names
CG8596-PA
CG8596-PB
CG8596-PC
Cln7-PA
Cln7-PB
Cln7-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7341884..7345183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139850.4 → NP_648107.3  Cln7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648107.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0M3, Q9VS51
    Related
    FBpp0076591
    Conserved Domains (2) summary
    cd06174
    Location:37 → 479
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:40 → 449
    MFS_1; Major Facilitator Superfamily

  2. NM_001274580.1 → NP_001261509.1  Cln7, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0M3, Q9VS51
    Conserved Domains (2) summary
    cd06174
    Location:37 → 479
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:40 → 449
    MFS_1; Major Facilitator Superfamily

  3. NM_001274579.1 → NP_001261508.1  Cln7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0M3, Q9VS51
    Conserved Domains (2) summary
    cd06174
    Location:37 → 479
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:40 → 449
    MFS_1; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VS51 Q9VS51

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