NANOGP8 Nanog homeobox retrogene P8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NANOGP8provided by HGNC
Official Full Name: Nanog homeobox retrogene P8provided by HGNC
Primary source: HGNC:HGNC:23106
See related: Ensembl:ENSG00000255192 AllianceGenome:HGNC:23106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PN8; NANOGP1
Summary: This gene represents a transcribed retrogene of the Nanog homeobox gene. The putative encoded protein may participate in reprogramming of cancer cells. In vitro studies using a recombinant protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to the Nanog protein. [provided by RefSeq, Sep 2017]
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Genomic context

Location:: 15q14

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (35083410..35085295, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (32888615..32890498, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (35375611..35377496, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Restriction Endonuclease-Based Assay to Distinguish NANOGP8 Retrogene from Parental NANOG.
Title: A Restriction Endonuclease-Based Assay to Distinguish NANOGP8 Retrogene from Parental NANOG.
NANOGP8 is the main regulator of gastric cancer stem cells. NANOGP8 is correlated with cell proliferation, migration, invasion, clonogenic capacity, beta-catenin accumulation in nucleus, and chemoresistance in gastric cancer.
Title: NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells.
studies demonstrated a paracrine role for endothelial cells in regulating the cancer stem cells phenotype and chemoresistance in colorectal cancer cells by AKT-mediated induction of NANOGP8.
Title: Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion.
LGR5-expressing fraction of CD54+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT core genes
Title: LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1.
Results indicate that NANOG and NANOGP8 proteins are expressed in prostate cancer cell lines, and NANOG and NANOGP8 equally contribute to the high malignant potential of prostate cancer.
Title: CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells.
NANOGP8 has a close relationship with the proliferation, cycle, apoptosis, migration and invasion of SGC-7901 gastric cancer cells
Title: [The expression of retrogene Nanogp8 is related to the biological characteristics of human SGC-7901 gastric cancer cells].
Unique biochemical properties of Nanog1 in embryonal carcinoma cells and NanogP8 in somatic cancer cells.
Title: Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.
These results show that cancer-associated NANOGP8 can contribute to promote de-differentiation and/or cellular plasticity.
Title: Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer.
High levels of NanogP8 may disrupt normal developmental programs and inhibit tumor development by depleting stem cells.
Title: In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals.
A comparative genomic approach identifies a series of retrotranspositional and mutational events that allowed NANOGP8 to evolve as a human-specific retro-oncogene.
Title: NANOGP8: evolution of a human-specific retro-oncogene.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell cycle G1/S phase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein NANOGP8

Names: nanog-like protein; putative homeobox protein NANOGP8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.