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TMEM233 transmembrane protein 233 [ Homo sapiens (human) ]

Gene ID: 387890, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM233provided by HGNC
Official Full Name
transmembrane protein 233provided by HGNC
Primary source
HGNC:HGNC:37219
See related
Ensembl:ENSG00000224982 MIM:618296; AllianceGenome:HGNC:37219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSPB2; IFITMD2
Summary
Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 3.9), brain (RPKM 1.9) and 1 other tissue See more
Orthologs
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Genomic context

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See TMEM233 in Genome Data Viewer
Location:
12q24.23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (119593774..119654295)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (119581202..119641838)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120031579..120080880)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr12:119745461-119745962 Neighboring gene long intergenic non-protein coding RNA 934 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:119807339-119808538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7114 Neighboring gene coiled-coil domain containing 60 Neighboring gene uncharacterized LOC105370027 Neighboring gene NANOG hESC enhancer GRCh37_chr12:119828163-119828664 Neighboring gene NANOG hESC enhancer GRCh37_chr12:119861020-119861540 Neighboring gene MPRA-validated peak2000 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:119924434-119924986 Neighboring gene MPRA-validated peak2001 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120031567-120032140 Neighboring gene RN7SK pseudogene 197 Neighboring gene GATA motif-containing MPRA enhancer 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120106633-120107268 Neighboring gene uncharacterized LOC124903033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115207-120115708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115709-120116208 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:120117012-120118211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120125555-120126425 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 1 Neighboring gene microRNA 1178 Neighboring gene citron rho-interacting serine/threonine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Benefits of random-priming: exhaustive survey of a cDNA library from lung tissue of a SARS patient. Wu H, et al. J Med Virol, 2011 Apr. PMID 21328370, Free PMC Article
  2. The dispanins: a novel gene family of ancient origin that contains 14 human members. Sällman Almén M, et al. PLoS One, 2012. PMID 22363774, Free PMC Article
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 233
Names
dispanin subfamily B member 2
interferon induced transmembrane protein domain containing 2
interferon-induced transmembrane domain-containing protein D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136534.3 → NP_001130006.1  transmembrane protein 233

    See identical proteins and their annotated locations for NP_001130006.1

    Status: VALIDATED

    Source sequence(s)
    AA476740, AC002563, DC315309, GD264605
    Consensus CDS
    CCDS44995.1
    UniProtKB/Swiss-Prot
    B4DJY2
    Related
    ENSP00000403130.1, ENST00000426426.3
    Conserved Domains (1) summary
    pfam04505
    Location:33 → 88
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    119593774..119654295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538329.3 → XP_011536631.1  transmembrane protein 233 isoform X2

    See identical proteins and their annotated locations for XP_011536631.1

    Conserved Domains (1) summary
    pfam04505
    Location:33 → 88
    CD225; Interferon-induced transmembrane protein

  2. XM_011538330.3 → XP_011536632.1  transmembrane protein 233 isoform X3

    Conserved Domains (1) summary
    pfam04505
    Location:29 → 88
    CD225; Interferon-induced transmembrane protein

  3. XM_005253881.4 → XP_005253938.1  transmembrane protein 233 isoform X2

    See identical proteins and their annotated locations for XP_005253938.1

    Conserved Domains (1) summary
    pfam04505
    Location:33 → 88
    CD225; Interferon-induced transmembrane protein

  4. XM_011538328.4 → XP_011536630.1  transmembrane protein 233 isoform X2

    See identical proteins and their annotated locations for XP_011536630.1

    Conserved Domains (1) summary
    pfam04505
    Location:33 → 88
    CD225; Interferon-induced transmembrane protein

  5. XM_011538331.4 → XP_011536633.1  transmembrane protein 233 isoform X4

    Conserved Domains (1) summary
    pfam04505
    Location:29 → 88
    CD225; Interferon-induced transmembrane protein

  6. XM_005253880.4 → XP_005253937.1  transmembrane protein 233 isoform X1

    Conserved Domains (1) summary
    pfam04505
    Location:29 → 88
    CD225; Interferon-induced transmembrane protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    119581202..119641838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372039.1 → XP_054228014.1  transmembrane protein 233 isoform X3

  2. XM_054372038.1 → XP_054228013.1  transmembrane protein 233 isoform X2

  3. XM_054372036.1 → XP_054228011.1  transmembrane protein 233 isoform X2

  4. XM_054372037.1 → XP_054228012.1  transmembrane protein 233 isoform X2

  5. XM_054372040.1 → XP_054228015.1  transmembrane protein 233 isoform X4

  6. XM_054372035.1 → XP_054228010.1  transmembrane protein 233 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B4DJY2.1 GenPept UniProtKB/Swiss-Prot:B4DJY2

Gene LinkOut

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