vvl ventral veins lacking [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: vvlprovided by FlyBase
Official Full Name: ventral veins lackingprovided by FlyBase
Primary source: FLYBASE:FBgn0086680
Locus tag: Dmel_CG10037
See related: AllianceGenome:FB:FBgn0086680
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cf1-a; Cf1a; CF1A; Cf1a/drifter; Cf1a/drifter/vvl; Cfla; CG10037; dfr; Dfr; DFR; dfr-vvl; dfr/vvl; Dfr/Vvl; Dmel\CG10037; drf; Drf; prd3; sep; ut; Vv1; Vvl; VVL; vvl/dfr; vvl/dfr/ut
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in nervous system development; positive regulation of macromolecule biosynthetic process; and regulation of dendrite morphogenesis. Located in nucleus. Is expressed in several structures, including adult optic lobe neurons; adult uniglomerular antennal lobe projection neuron lPN; epithelium; ganglia; and gut section. Human ortholog(s) of this gene implicated in X-linked deafness 2. Orthologous to several human genes including POU3F4 (POU class 3 homeobox 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 65C5-65C5; 3-17 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6790158..6794941)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6783258..6788041)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Grh and Vvl participate in a regulatory network controlling epithelial maturation.
Title: Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl.
Vvl is highly expressed in the prothoracic gland during embryogenesis and is enriched in the gland during larval development, suggesting that Vvl might function as a master transcriptional regulator in this tissue.
Title: Transcriptional control of steroid biosynthesis genes in the Drosophila prothoracic gland by ventral veins lacking and knirps.
Dfr/Vvl is highly expressed in a range of immunocompetent tissues, including the male ejaculatory duct, where its presence overlaps with and drives the expression of cecropin
Title: The POU transcription factor Drifter/Ventral veinless regulates expression of Drosophila immune defense genes.
From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons.
Title: From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons.
the class III POU protein, Drifter (Ventral veinless), is co-expressed with Islet and Lim3 specifically in the ISNb motoneuron subclass
Title: Specification of Drosophila motoneuron identity by the combinatorial action of POU and LIM-HD factors.
multiple roles for u-turn/ventral veinless in the development of the peripheral nervous system
Title: Multiple roles for u-turn/ventral veinless in the development of Drosophila PNS.
vvl acts downstream of the Hox gene lab and regulates specific aspects of neuronal differentiation within the tritocerebral neuromere during embryonic brain development
Title: ventral veins lacking is required for specification of the tritocerebrum in embryonic brain development of Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of antimicrobial peptide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ventral veins lacking

Names: CG10037-PA; CG10037-PC; CG10037-PD; CG10037-PE; CG10037-PF; Drifter/Ventral veinless; PRD gene 3; U-turned; drifter; paired-like 3; separated; u-turn; ventral veinless; vvl-PA; vvl-PC; vvl-PD; vvl-PE; vvl-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6790158..6794941

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300028.1 → NP_001286957.1 ventral veins lacking, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286957.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16241, Q24460, Q86P26, Q9VRY9

UniProtKB/TrEMBL

A8E6G8

Conserved Domains (2) summary

smart00352
Location:212 → 286

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:307 → 361

Homeobox; Homeobox domain
NM_079224.5 → NP_523948.1 ventral veins lacking, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523948.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16241, Q24460, Q86P26, Q9VRY9

UniProtKB/TrEMBL

A8E6G8

Related

FBpp0076653

Conserved Domains (2) summary

smart00352
Location:212 → 286

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:307 → 361

Homeobox; Homeobox domain
NM_001169884.2 → NP_001163355.2 ventral veins lacking, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163355.2

Status: REVIEWED

UniProtKB/TrEMBL

E1JI48

Conserved Domains (2) summary

smart00352
Location:212 → 286

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:307 → 360

Homeobox; Homeobox domain
NM_001316454.1 → NP_001303383.1 ventral veins lacking, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WNN1

Conserved Domains (2) summary

smart00352
Location:212 → 286

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:307 → 360

Homeobox; Homeobox domain
NM_001316455.1 → NP_001303384.1 ventral veins lacking, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WGV5

Conserved Domains (2) summary

smart00352
Location:212 → 286

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:307 → 360

Homeobox; Homeobox domain