sfl sulfateless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sflprovided by FlyBase
Official Full Name: sulfatelessprovided by FlyBase
Primary source: FLYBASE:FBgn0020251
Locus tag: Dmel_CG8339
See related: AllianceGenome:FB:FBgn0020251
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8339; CT24567; Dmel\CG8339; dw; l(3)03844; lincRNA.S4253; Ndst; NDST; Sfl; SFL
Summary: Enables sulfotransferase activity. Involved in several processes, including epithelial cell migration, open tracheal system; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; and imaginal disc-derived wing morphogenesis. Acts upstream of with a positive effect on fibroblast growth factor receptor signaling pathway. Located in Golgi cis cisterna and endoplasmic reticulum. Is expressed in adult head; embryonic/larval antennal lobe glomerulus; larval mushroom body calyx glomerulus; organism; and projection neurons. Used to study autism spectrum disorder; azoospermia; and intellectual disability. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to several human genes including NDST1 (N-deacetylase and N-sulfotransferase 1); NDST2 (N-deacetylase and N-sulfotransferase 2); and NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: 65B3-65B4; 3-17 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6495680..6550104)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6488780..6543204)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparan sulfate N-deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables sulfotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosaminoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfur compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cis cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sulfateless

Names: CG8339-PA; CG8339-PB; CG8339-PC; CG8339-PD; HS N-deacetylase/N-sulfotransferase; diet-wingless; sfl-PA; sfl-PB; sfl-PC; sfl-PD

NP_001163354.1

EC 2.8.2.-

EC 2.8.2.8

EC 3.-.-.-

EC 3.1.1.-

NP_001401031.1

EC 2.8.2.-

EC 2.8.2.8

EC 3.-.-.-

EC 3.1.1.-

NP_001401032.1

EC 2.8.2.-

EC 2.8.2.8

EC 3.-.-.-

EC 3.1.1.-

NP_523946.1

EC 2.8.2.-

EC 2.8.2.8

EC 3.-.-.-

EC 3.1.1.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6495680..6550104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079222.5 → NP_523946.1 sulfateless, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523946.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3L1

UniProtKB/TrEMBL

E1JID8

Related

FBpp0076677

Conserved Domains (2) summary

pfam00685
Location:758 → 1017

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:179 → 669

HSNSD; heparan sulfate-N-deacetylase
NM_001414148.1 → NP_001401031.1 sulfateless, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A9F2H0Y2
NM_001169883.3 → NP_001163354.1 sulfateless, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163354.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3L1

UniProtKB/TrEMBL

E1JID8

Conserved Domains (2) summary

pfam00685
Location:758 → 1017

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:179 → 669

HSNSD; heparan sulfate-N-deacetylase
NM_001414149.1 → NP_001401032.1 sulfateless, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q4V3Y9