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MTCL3 MTCL family member 3 [ Homo sapiens (human) ]

Gene ID: 387104, updated on 2-Nov-2024

Summary

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Official Symbol
MTCL3provided by HGNC
Official Full Name
MTCL family member 3provided by HGNC
Primary source
HGNC:HGNC:21494
See related
Ensembl:ENSG00000214338 AllianceGenome:HGNC:21494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOGA3; C6orf174; dJ403A15.3
Summary
Predicted to be involved in regulation of autophagy. Predicted to be located in extracellular space and membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 11.8), fat (RPKM 5.6) and 13 other tissues See more
Orthologs
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Genomic context

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See MTCL3 in Genome Data Viewer
Location:
6q22.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (127472974..127519335, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (128661901..128708261, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (127794119..127840480, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SOGA3-KIAA0408 readthrough Neighboring gene KIAA0408 Neighboring gene uncharacterized LOC124901399 Neighboring gene Sharpr-MPRA regulatory region 7566 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:127802337-127803536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25041 Neighboring gene uncharacterized LOC107986642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:127835952-127836476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17530 Neighboring gene chromosome 6 open reading frame 58 Neighboring gene uncharacterized LOC105377995

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. Ku WC, et al. Mol Cell Proteomics, 2009 Sep. PMID 19505873, Free PMC Article
  2. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. Emdal KB, et al. Sci Signal, 2015 Apr 28. PMID 25921289
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  5. TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing. Demirdizen E, et al. Neuro Oncol, 2023 Jun 2. PMID 36215168, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough SOGA3-KIAA0408

Readthrough gene: SOGA3-KIAA0408, Included gene: KIAA0408

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule cross-linking factor 3
Names
SOGA family member 3
protein SOGA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400265.1 → NP_001387194.1  microtubule cross-linking factor 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL096711, AL583806
    Consensus CDS
    CCDS43505.1
    UniProtKB/Swiss-Prot
    Q5TF21
    Related
    ENSP00000434570.1, ENST00000525778.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    127472974..127519335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    128661901..128708261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012279.3: Suppressed sequence

    Description
    NM_001012279.3: This RefSeq was removed because currently there is insufficient support for the transcript.

  2. NM_001395923.1: Suppressed sequence

    Description
    NM_001395923.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  3. NM_001395924.1: Suppressed sequence

    Description
    NM_001395924.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  4. NM_001395925.1: Suppressed sequence

    Description
    NM_001395925.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  5. NM_001395926.1: Suppressed sequence

    Description
    NM_001395926.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  6. NM_001395928.1: Suppressed sequence

    Description
    NM_001395928.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  7. NM_001395929.1: Suppressed sequence

    Description
    NM_001395929.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TF21.1 GenPept UniProtKB/Swiss-Prot:Q5TF21

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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