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ZKSCAN4 zinc finger with KRAB and SCAN domains 4 [ Homo sapiens (human) ]

Gene ID: 387032, updated on 7-Apr-2024

Summary

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Official Symbol
ZKSCAN4provided by HGNC
Official Full Name
zinc finger with KRAB and SCAN domains 4provided by HGNC
Primary source
HGNC:HGNC:13854
See related
Ensembl:ENSG00000187626 MIM:611643; AllianceGenome:HGNC:13854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF307; ZNF427; ZSCAN36; P1P373C6
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.9), spleen (RPKM 2.1) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6p22.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28241697..28259211, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28113435..28131010, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28209475..28226989, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28184762-28184955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24348 Neighboring gene transducer of ERBB2, 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24349 Neighboring gene zinc finger and SCAN domain containing 9 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:28203630-28204444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17043 Neighboring gene NFKB activating protein like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:28234963-28235527 Neighboring gene zinc finger and SCAN domain containing 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma. Liang Y, et al. Oncol Rep, 2017 Oct. PMID 28765950
  2. ZNF307 (Zinc Finger Protein 307) Acts as a Negative Regulator of Pressure Overload-Induced Cardiac Hypertrophy. Yu CJ, et al. Hypertension, 2017 Apr. PMID 28223477
  3. A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. Ecker K, et al. J Mol Endocrinol, 2009 Feb. PMID 19008334
  4. ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway. Li J, et al. Biochem Biophys Res Commun, 2007 Nov 30. PMID 17910948
  5. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Yue WH, et al. Nat Genet, 2011 Oct 30. PMID 22037552

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our results indicate that ZNF307 may serve as a tumor suppressor and inhibits cell proliferation of hepatocellular carcinoma via inducing apoptosis
    Title: Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma.
  2. ZNF307 ameliorates pressure overload-induced cardiac hypertrophy by inhibiting the activity of NF-kappaB-signaling pathway
    Title: ZNF307 (Zinc Finger Protein 307) Acts as a Negative Regulator of Pressure Overload-Induced Cardiac Hypertrophy.
  3. The SCAN- and KRAB-domain-containing zinc finger protein 307 (ZKSCAN4) was co-precipitated with the receptor when both proteins were overexpressed in HEK293 cells.
    Title: A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein.
  4. ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation
    Title: ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
zinc finger protein with KRAB and SCAN domains 4
Names
p373c6.1 (novel C2H2 type zinc finger protein)
zinc finger protein 307
zinc finger protein 427

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304506.2 → NP_001291435.1  zinc finger protein with KRAB and SCAN domains 4 isoform 2

    See identical proteins and their annotated locations for NP_001291435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK302017, AL022393
    UniProtKB/TrEMBL
    B7Z7H3, C9JSR9
    Conserved Domains (6) summary
    smart00349
    Location:66 → 126
    KRAB; krueppel associated box
    COG5048
    Location:219 → 389
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:165 → 187
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:69 → 104
    KRAB; KRAB box
    pfam13465
    Location:235 → 260
    zf-H2C2_2; Zinc-finger double domain

  2. NM_019110.5 → NP_061983.2  zinc finger protein with KRAB and SCAN domains 4 isoform 1

    See identical proteins and their annotated locations for NP_061983.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL022393, AY781778, HY070446
    Consensus CDS
    CCDS4647.1
    UniProtKB/Swiss-Prot
    B2RE32, Q5U7L4, Q969J2
    UniProtKB/TrEMBL
    A0A0S2Z658
    Related
    ENSP00000366509.2, ENST00000377294.3
    Conserved Domains (6) summary
    smart00431
    Location:49 → 160
    SCAN; leucine rich region
    smart00349
    Location:221 → 281
    KRAB; krueppel associated box
    COG5048
    Location:374 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:378 → 398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320 → 342
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:335 → 357
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    28241697..28259211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418753.1 → XP_047274709.1  zinc finger protein with KRAB and SCAN domains 4 isoform X5

    UniProtKB/TrEMBL
    B7Z7H3, C9JSR9

  2. XM_047418754.1 → XP_047274710.1  zinc finger protein with KRAB and SCAN domains 4 isoform X4

  3. XM_005249095.4 → XP_005249152.1  zinc finger protein with KRAB and SCAN domains 4 isoform X1

    See identical proteins and their annotated locations for XP_005249152.1

    UniProtKB/Swiss-Prot
    B2RE32, Q5U7L4, Q969J2
    UniProtKB/TrEMBL
    A0A0S2Z658
    Conserved Domains (6) summary
    smart00431
    Location:49 → 160
    SCAN; leucine rich region
    smart00349
    Location:221 → 281
    KRAB; krueppel associated box
    COG5048
    Location:374 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:378 → 398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320 → 342
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:335 → 357
    zf-H2C2_2; Zinc-finger double domain

  4. XM_005249098.4 → XP_005249155.1  zinc finger protein with KRAB and SCAN domains 4 isoform X3

    See identical proteins and their annotated locations for XP_005249155.1

    Conserved Domains (5) summary
    smart00349
    Location:118 → 178
    KRAB; krueppel associated box
    COG5048
    Location:271 → 441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:275 → 295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:217 → 239
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:232 → 254
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011514588.4 → XP_011512890.1  zinc finger protein with KRAB and SCAN domains 4 isoform X2

    Conserved Domains (8) summary
    smart00431
    Location:49 → 131
    SCAN; leucine rich region
    smart00349
    Location:192 → 252
    KRAB; krueppel associated box
    COG5048
    Location:345 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:349 → 369
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:347 → 369
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:195 → 230
    KRAB; KRAB box
    pfam02023
    Location:49 → 113
    SCAN; SCAN domain
    pfam13465
    Location:361 → 386
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011514589.3 → XP_011512891.1  zinc finger protein with KRAB and SCAN domains 4 isoform X5

    See identical proteins and their annotated locations for XP_011512891.1

    UniProtKB/TrEMBL
    B7Z7H3, C9JSR9
    Conserved Domains (6) summary
    smart00349
    Location:66 → 126
    KRAB; krueppel associated box
    COG5048
    Location:219 → 389
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:165 → 187
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:69 → 104
    KRAB; KRAB box
    pfam13465
    Location:235 → 260
    zf-H2C2_2; Zinc-finger double domain

  7. XM_047418755.1 → XP_047274711.1  zinc finger protein with KRAB and SCAN domains 4 isoform X5

    UniProtKB/TrEMBL
    B7Z7H3, C9JSR9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    28113435..28131010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355386.1 → XP_054211361.1  zinc finger protein with KRAB and SCAN domains 4 isoform X6

  2. XM_054355390.1 → XP_054211365.1  zinc finger protein with KRAB and SCAN domains 4 isoform X4

  3. XM_054355387.1 → XP_054211362.1  zinc finger protein with KRAB and SCAN domains 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RE32, Q5U7L4, Q969J2
    UniProtKB/TrEMBL
    A0A0S2Z658

  4. XM_054355389.1 → XP_054211364.1  zinc finger protein with KRAB and SCAN domains 4 isoform X3

  5. XM_054355388.1 → XP_054211363.1  zinc finger protein with KRAB and SCAN domains 4 isoform X2

  6. XM_054355392.1 → XP_054211367.1  zinc finger protein with KRAB and SCAN domains 4 isoform X5

    UniProtKB/TrEMBL
    B7Z7H3, C9JSR9

  7. XM_054355391.1 → XP_054211366.1  zinc finger protein with KRAB and SCAN domains 4 isoform X5

    UniProtKB/TrEMBL
    B7Z7H3, C9JSR9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969J2.1 GenPept UniProtKB/Swiss-Prot:Q969J2

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