adam13.L ADAM metallopeptidase domain 13 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: adam13.L
Official Full Name: ADAM metallopeptidase domain 13 L homeolog
Primary source: Xenbase:XB-GENE-988112
Locus tag: XELAEV_18004895mg
See related: EnsemblRapid:ENSXLAG00005020945 AllianceGenome:Xenbase:XB-GENE-988112
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: .L; adam13; adam33; adam33.L
Summary: Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Is expressed in ectoderm; musculoskeletal system; nervous system; and visual system. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and rhinitis. Orthologous to human ADAM33 (ADAM metallopeptidase domain 33). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 1L

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (10388580..10453625, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (7129622..7194655)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, the authors show that adam13 interacts with the arid3a/dril1/Bright transcription factor. This interaction promotes a proteolytic cleavage of arid3a and its translocation to the nucleus where it regulates another transcription factor: tfap2alpha. Tfap2alpha in turn activates multiple genes including the protocadherin pcdh8l (PCNS).
Title: Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a.
Increased ADAM13 cleavage of cadherin 11produces the EC1-3 fragment which increases cranial neural crest cell invasiveness in vitro and blocks the repulsive contact inhibition of locomotion response in colliding cells.
Title: ADAM13 cleavage of cadherin-11 promotes CNC migration independently of the homophilic binding site.
Novel roles for Plk and GSK3 regulation of ADAM13 function in cranial neural crest cell migration.
Title: GSK3 and Polo-like kinase regulate ADAM13 function during cranial neural crest cell migration.
Data show that ADAM13 function is autonomous to cranial neural crest (CNC) tissue.
Title: ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis.
The cytoplasmic domain of ADAM13 regulates the expression of multiple genes in cranial neural crest, including the protease Calpain8-a.
Title: Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADAM metallopeptidase domain 13 L homeolog

Names: ADAM metallopeptidase domain 33 L homeolog; L homeolog; a disintegrin and metalloprotease domain 13; x-adam 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087445.1 → NP_001080914.1 ADAM metallopeptidase domain 13 L homeolog

See identical proteins and their annotated locations for NP_001080914.1

Status: PROVISIONAL

Source sequence(s)

U66003

UniProtKB/TrEMBL

B7ZQX1, O12960

Related

ENSXLAP00005061518.1, ENSXLAT00005062971.1

Conserved Domains (5) summary

smart00050
Location:420 → 494

DISIN; Homologues of snake disintegrins

smart00608
Location:496 → 637

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:205 → 401

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:205 → 403

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:47 → 164

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

10388580..10453625 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)