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CHRNA3 cholinergic receptor nicotinic alpha 3 subunit [ Gallus gallus (chicken) ]

Gene ID: 386578, updated on 17-Aug-2024

Summary

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Official Symbol
CHRNA3provided by CGNC
Official Full Name
cholinergic receptor nicotinic alpha 3 subunitprovided by CGNC
Primary source
CGNC:49156
See related
Ensembl:ENSGALG00010024167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See CHRNA3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (3643903..3650737)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (3519100..3525933)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor nicotinic beta 4 subunit Neighboring gene uncharacterized LOC121111656 Neighboring gene cholinergic receptor nicotinic alpha 5 subunit Neighboring gene proteasome subunit alpha 4 Neighboring gene uncharacterized LOC121111655 Neighboring gene hydroxylysine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type. Fernandes CC, et al. J Neurosci, 2010 Jun 30. PMID 20592206, Free PMC Article
  2. Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex. Rosenberg MM, et al. Mol Cell Neurosci, 2008 Jun. PMID 18407517, Free PMC Article
  3. Alpha 5, alpha 3, and non-alpha 3. Three clustered avian genes encoding neuronal nicotinic acetylcholine receptor-related subunits. Couturier S, et al. J Biol Chem, 1990 Oct 15. PMID 1698777
  4. Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit compositions. Conroy WG, et al. J Biol Chem, 1995 Mar 3. PMID 7876208
  5. Chick optic lobe contains a developmentally regulated alpha2alpha5beta2 nicotinic receptor subtype. Balestra B, et al. Mol Pharmacol, 2000 Aug. PMID 10908297

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nAChR alpha3 and alpha7 lateral mobility is controlled by domain specific, receptor subtype dependent, and cell-type constrained mechanisms; this system could tailor nicotinic signaling capabilities to specific needs of individual locations
    Title: Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type.
  2. APC interaction with microtubule plus-end binding protein EB1 is required for alpha3(*)nAChR surface membrane insertion and stabilization
    Title: Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neuronal acetylcholine receptor subunit alpha-3
Names
cholinergic receptor, nicotinic, alpha 3 (neuronal)
cholinergic receptor, nicotinic, alpha polypeptide 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204416.2 → NP_989747.1  neuronal acetylcholine receptor subunit alpha-3 precursor

    See identical proteins and their annotated locations for NP_989747.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000245
    UniProtKB/Swiss-Prot
    P09481
    UniProtKB/TrEMBL
    A0A8V0ZR45
    Related
    ENSGALP00010035916.1, ENSGALT00010058951.1
    Conserved Domains (3) summary
    TIGR00860
    Location:5 → 487
    LIC; Cation transporter family protein
    pfam02931
    Location:26 → 232
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:239 → 486
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3643903..3650737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3519100..3525933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09481.2 GenPept UniProtKB/Swiss-Prot:P09481

Gene LinkOut

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