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S6k Ribosomal protein S6 kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38654, updated on 18-Sep-2024

Summary

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Official Symbol
S6kprovided by FlyBase
Official Full Name
Ribosomal protein S6 kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0283472
Locus tag
Dmel_CG10539
See related
AllianceGenome:FB:FBgn0283472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
10539; 7-10; 7084; CG10539; d-S6K; Dmel\CG10539; dp70s6k; dP70S6K; Dp70s6k; Dp70S6k; dp70[S6k]; Dp70[s6k]; dps6k; ds6k; dS6k; dS6K; DS6K; dS6K1; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70s6K; p70S6k; p70S6K; p70[S6 kinase]; p70[S6kinase]; p70[S6k]; p70[S6K]; Pk64F; Pk?6; pS6K; S6; S6 K; s6k; S6K; S6K1; s6k11
Summary
Enables ribosomal protein S6 kinase activity. Involved in several processes, including female germ-line stem cell population maintenance; nervous system development; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in presynaptic active zone. Is expressed in adult brain and adult head. Used to study alcohol dependence and type 2 diabetes mellitus. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1) and RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See S6k in Genome Data Viewer
Location:
64E8-64E11; 3-15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5797549..5810931, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5790649..5804031, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Bre1 Neighboring gene Tektin C Neighboring gene uncharacterized protein Neighboring gene krishah Neighboring gene mad2 Neighboring gene vein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster. Cho I, et al. DNA Cell Biol, 2010 Sep. PMID 20491566, Free PMC Article
  2. The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity. Stewart MJ, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855259, Free PMC Article
  3. Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila. Schinaman JM, et al. Sci Rep, 2019 May 24. PMID 31127145, Free PMC Article
  4. Flos Chrysanthemi Indici extract improves a high-sucrose diet-induced metabolic disorder in Drosophila. Bai Y, et al. Exp Ther Med, 2018 Sep. PMID 30186490, Free PMC Article
  5. Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila. Villa-Cuesta E, et al. J Cell Sci, 2014 May 15. PMID 24610944, Free PMC Article

See all (505) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models.
    Title: Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models.
  2. Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.
    Title: Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.
  3. Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
    Title: Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
  4. The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila.
    Title: The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila.
  5. mTOR-S6K1 pathway mediates cytoophidium assembly
    Title: mTOR-S6K1 pathway mediates cytoophidium assembly.
  6. Findings indicate that Archipelago (Ago)/FBXW7 controls S6kinase (dS6K) protein levels, but do not impinge on the transcript level.
    Title: A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7.
  7. MYC and S6K cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A.
    Title: S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.
  8. This study showed that p70 S6 kinase (S6k), acting downstream of the insulin receptor (InR) and the small GTPase Arf6, is a key mediator of ethanol-induced sedation in Drosophila
    Title: S6 Kinase Reflects and Regulates Ethanol-Induced Sedation.
  9. our results indicate that S6K1 has an inhibitory effect on autophagic activity under normal nutritional conditions
    Title: TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1.
  10. S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development
    Title: S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal protein S6 kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of response to drug IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of terminal button organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
located_in nucleoplasm HDA PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosomal protein S6 kinase
Names
CG10539-PA
CG10539-PB
RPS6-p70-protein kinase
S6 kinase
S6-kinase
S6K kinase
S6k-PA
S6k-PB
S6kinase
dS6 kinase
p70 S6 kinase
p70 S6 kinase 1
p70 ribosomal S6 kinase
p70S6 kinase
p70S6K kinase
protein kinase-like 64F
ribosomal S6 protein kinase
NP_001261450.1
NP_523941.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5797549..5810931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274521.1 → NP_001261450.1  ribosomal protein S6 kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261450.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1ZYE3, Q94533
    Conserved Domains (2) summary
    PTZ00263
    Location:76 → 397
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd05584
    Location:81 → 402
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  2. NM_079217.3 → NP_523941.2  ribosomal protein S6 kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523941.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1ZYE3, Q94533
    Related
    FBpp0076820
    Conserved Domains (2) summary
    PTZ00263
    Location:76 → 397
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd05584
    Location:81 → 402
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91656 P91656
Q8SWT5 Q8SWT5
Q94533 Q94533

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