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Ras64B Ras oncogene at 64B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38494, updated on 2-Nov-2024

Summary

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Official Symbol
Ras64Bprovided by FlyBase
Official Full Name
Ras oncogene at 64Bprovided by FlyBase
Primary source
FLYBASE:FBgn0003206
Locus tag
Dmel_CG1167
See related
AllianceGenome:FB:FBgn0003206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE36103; c-ras2; C-ras2; CG1167; D-ras-2; D-ras2; Dm-ras-64B; Dmel\CG1167; Dmras64B; Dras2; DRas2; Dras64B; ras; Ras; RAS; ras-2; ras2; Ras2; RAS2; RAS64B
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including female germline cell; ganglia; gonad; imaginal disc; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to several human genes including RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Ras64B in Genome Data Viewer
Location:
64A7-64A7; 3-10 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4139076..4141398)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4139076..4141398)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Replication factor C subunit 4 Neighboring gene Ras opposite Neighboring gene Adipokinetic hormone Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization and developmental expression of a Drosophila ras oncogene. Mozer B, et al. Mol Cell Biol, 1985 Apr. PMID 3921827, Free PMC Article
  2. Conserved cis-elements bind a protein complex that regulates Drosophila ras2/rop bidirectional expression. Lightfoot K, et al. Br J Cancer, 1994 Feb. PMID 8297724, Free PMC Article
  3. Interaction of mRNA with the C-Terminal Domain of PCID2, a Subunit of the TREX-2 Complex, Is Required for Its Export from the Nucleus to the Cytoplasm in Drosophila melanogaster. Vdovina YA, et al. Dokl Biochem Biophys, 2023 Dec. PMID 38066318, Free PMC Article
  4. Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex. Kurshakova MM, et al. Dokl Biochem Biophys, 2024 Oct. PMID 39196529
  5. The Drosophila Ras2 and Rop gene pair: a dual homology with a yeast Ras-like gene and a suppressor of its loss-of-function phenotype. Salzberg A, et al. Development, 1993 Apr. PMID 8404533

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex.
    Title: Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex.
  2. Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability.
    Title: Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability.
  3. According to Bridges' map, all three bands (Dras1, Dras2, Dras3) were mapped to regions 85D, 64B, and 62B of chromosome 3. Among them, only Drasl has a common origin with ras genes of mammals.
    Title: [Universal intracellular transducer RAS and its role in the development of Drosophila].
  4. Our evidence suggests that tumors can evolve into malignancy through oncogenic Ras activation and the hijacking of TNF signaling.
    Title: Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ras oncogene at 64B
Names
CG1167-PA
Ras64B-PA
ras oncogene
small GTP binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4139076..4141398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079193.4 → NP_523917.2  Ras oncogene at 64B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523917.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P04388, Q9VZH7
    Related
    FBpp0073068
    Conserved Domains (1) summary
    cd04145
    Location:4 → 167
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04388.2 P04388

Gene LinkOut

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