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Adam20 a disintegrin and metallopeptidase domain 20 [ Mus musculus (house mouse) ]

Gene ID: 384806, updated on 17-Aug-2024

Summary

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Official Symbol
Adam20provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 20provided by MGI
Primary source
MGI:MGI:2152342
See related
Ensembl:ENSMUSG00000046282 AllianceGenome:MGI:2152342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adam38; 4930529F22Rik
Summary
Predicted to be involved in male gonad development. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Is expressed in testis. Orthologous to human ADAM20 (ADAM metallopeptidase domain 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 23.2) See more
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Genomic context

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See Adam20 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41246310..41250379)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40793273..40797342)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 39 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6b pseudogene Neighboring gene a disintegrin and metallopeptidase domain 39 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis. Nandadasa S, et al. Nat Commun, 2019 Feb 27. PMID 30814516, Free PMC Article
  2. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testase-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009548.2 → NP_001009548.1  testase-8

    See identical proteins and their annotated locations for NP_001009548.1

    Status: VALIDATED

    Source sequence(s)
    AK133113
    Consensus CDS
    CCDS40325.1
    UniProtKB/TrEMBL
    B2RX16, Q7M763
    Related
    ENSMUSP00000057794.8, ENSMUST00000056331.8
    Conserved Domains (4) summary
    smart00608
    Location:505 → 641
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:222 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:429 → 501
    Disintegrin
    pfam01562
    Location:57 → 173
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41246310..41250379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509453.1 → XP_006509516.1  testase-8 isoform X1

    See identical proteins and their annotated locations for XP_006509516.1

    UniProtKB/TrEMBL
    B2RX16, Q7M763
    Conserved Domains (4) summary
    smart00608
    Location:505 → 641
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:222 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:429 → 501
    Disintegrin
    pfam01562
    Location:57 → 173
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein Strain
Heading Accession and Version

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