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FoxL1 Forkhead box L1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38471, updated on 2-Nov-2024

Summary

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Official Symbol
FoxL1provided by FlyBase
Official Full Name
Forkhead box L1provided by FlyBase
Primary source
FLYBASE:FBgn0004895
Locus tag
Dmel_CG1132
See related
AllianceGenome:FB:FBgn0004895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1132; Dmel\CG1132; Dmfd2; fd2; FD2; fd64A; Fd64A; foxL1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including embryonic hindgut; embryonic small intestine; embryonic thoracic segment; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in otosclerosis 11. Orthologous to human FOXL1 (forkhead box L1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See FoxL1 in Genome Data Viewer
Location:
64A4-64A4; 3-10 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4018878..4021279)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4018878..4021279)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene scratch Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial E3 ubiquitin protein ligase 1 Neighboring gene Gustatory receptor 64a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An ancient Fox gene cluster in bilaterian animals. Mazet F, et al. Curr Biol, 2006 May 9. PMID 16682334
  2. Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development. Hanlon CD, et al. Dev Biol, 2016 Nov 15. PMID 27618755, Free PMC Article
  3. Developmentally regulated Drosophila gene family encoding the fork head domain. Häcker U, et al. Proc Natl Acad Sci U S A, 1992 Sep 15. PMID 1356269, Free PMC Article
  4. Five years on the wings of fork head. Kaufmann E, et al. Mech Dev, 1996 Jun. PMID 8817449
  5. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Clark KL, et al. Nature, 1993 Jul 29. PMID 8332212

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
forkhead box L1
Names
CG1132-PA
CG1132-PB
FoxL1-PA
FoxL1-PB
forkhead domain 64A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4018878..4021279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259680.2 → NP_001246609.1  forkhead box L1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246609.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02360, Q9VZK0
    UniProtKB/TrEMBL
    D3PFH7
    Conserved Domains (1) summary
    smart00339
    Location:91 → 185
    FH; FORKHEAD

  2. NM_079188.3 → NP_523912.1  forkhead box L1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523912.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02360, Q9VZK0
    UniProtKB/TrEMBL
    D3PFH7
    Related
    FBpp0073048
    Conserved Domains (1) summary
    smart00339
    Location:91 → 185
    FH; FORKHEAD
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3PFH7 D3PFH7
Q02360.2 Q02360

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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