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Ccz1 Caffeine, calcium, zinc sensitivity 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38455, updated on 28-Oct-2024

Summary

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Official Symbol
Ccz1provided by FlyBase
Official Full Name
Caffeine, calcium, zinc sensitivity 1provided by FlyBase
Primary source
FLYBASE:FBgn0035470
Locus tag
Dmel_CG14980
See related
AllianceGenome:FB:FBgn0035470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
C7orf28B; CCZ1; CG14980; Dccz1; Dmel\CG14980; NP_647835
Summary
Contributes to guanyl-nucleotide exchange factor activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway. Located in cytosol. Part of Mon1-Ccz1 complex. Is expressed in adult head and organism. Orthologous to human CCZ1B (CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated) and CCZ1 (CCZ1 homolog, vacuolar protein trafficking and biogenesis associated). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See Ccz1 in Genome Data Viewer
Location:
63F5-63F5; 3-9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3897444..3899156, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3897444..3899156, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U11 Neighboring gene Fire exit Neighboring gene Gustatory receptor 63a Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene Ubiquitin-63E Neighboring gene Sc2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Yong X, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216550, Free PMC Article
  2. A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. Dehnen L, et al. J Cell Sci, 2020 Jul 9. PMID 32499409
  3. Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation. Borchers AC, et al. Proc Natl Acad Sci U S A, 2023 Jul 25. PMID 37463208, Free PMC Article
  4. Endosomal recycling protein Rab11 in Parkin and Pink1 signaling in Drosophila model of Parkinson's disease. Rai P, et al. Exp Cell Res, 2022 Nov 15. PMID 36116557
  5. A conserved and regulated mechanism drives endosomal Rab transition. Langemeyer L, et al. Elife, 2020 May 11. PMID 32391792, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome to lysosome transport via multivesicular body sorting pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Mon1-Ccz1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Mon1-Ccz1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Mon1-Ccz1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Caffeine, calcium, zinc sensitivity 1
Names
CG14980-PB
Ccz1 ortholog
Ccz1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3897444..3899156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139578.3 → NP_647835.1  Caffeine, calcium, zinc sensitivity 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647835.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SYB1, Q9VZL5
    Related
    FBpp0073036
    Conserved Domains (1) summary
    pfam08217
    Location:15 → 482
    DUF1712; Fungal domain of unknown function (DUF1712)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZL5 Q9VZL5
Q9VZL5.3

Gene LinkOut

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