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Ephx4 epoxide hydrolase 4 [ Mus musculus (house mouse) ]

Gene ID: 384214, updated on 2-Nov-2024

Summary

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Official Symbol
Ephx4provided by MGI
Official Full Name
epoxide hydrolase 4provided by MGI
Primary source
MGI:MGI:2686228
See related
Ensembl:ENSMUSG00000033805 AllianceGenome:MGI:2686228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abhd7; Ephxrp; Gm1382
Summary
Predicted to enable hydrolase activity. Predicted to be located in membrane. Orthologous to human EPHX4 (epoxide hydrolase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 18.7), frontal lobe adult (RPKM 11.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Ephx4 in Genome Data Viewer
Location:
5 E5- F; 5 52.23 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107551379..107577901)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107403513..107430035)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene bromodomain, testis-specific Neighboring gene predicted gene 17202 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene nuclear encoded rRNA 5S 173 Neighboring gene STARR-seq mESC enhancer starr_13889 Neighboring gene lysophosphatidylcholine acyltransferase 2B Neighboring gene BTB domain containing 8 Neighboring gene predicted gene, 33885

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation. Shen Y, et al. Cell Rep, 2024 Feb 27. PMID 38308845
  2. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Sirish P, et al. Proc Natl Acad Sci U S A, 2013 Apr 2. PMID 23493561, Free PMC Article
  3. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation.
    Title: ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epoxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
epoxide hydrolase 4
Names
abhydrolase domain containing 7
abhydrolase domain-containing protein 7
epoxide hydrolase-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001804.2 → NP_001001804.2  epoxide hydrolase 4 isoform 1

    See identical proteins and their annotated locations for NP_001001804.2

    Status: VALIDATED

    Source sequence(s)
    AC126598, BN000367
    Consensus CDS
    CCDS19501.1
    UniProtKB/Swiss-Prot
    F8VQ47, Q6IE26
    Related
    ENSMUSP00000043764.6, ENSMUST00000049146.12
    Conserved Domains (1) summary
    COG0596
    Location:74 → 353
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. NM_001379224.1 → NP_001366153.1  epoxide hydrolase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126598
    Conserved Domains (1) summary
    COG0596
    Location:1 → 260
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  3. NM_001379225.1 → NP_001366154.1  epoxide hydrolase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126598
    Conserved Domains (1) summary
    COG0596
    Location:1 → 260
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    107551379..107577901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IE26.2 GenPept UniProtKB/Swiss-Prot:Q6IE26

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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