Drs Drosomycin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Drsprovided by FlyBase
Official Full Name: Drosomycinprovided by FlyBase
Primary source: FLYBASE:FBgn0283461
Locus tag: Dmel_CG10810
See related: AllianceGenome:FB:FBgn0283461
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LP03851; CG10810; Crp; DIM 19; DIM 21; Dmel\CG10810; dmy1; drm; Drm; DRO; drom; Drom; DROM; dros; Dros; DROS; Droso; drosomycin; drs; DRS; drsm; IM21
Summary: Involved in several processes, including antimicrobial humoral response; defense response to protozoan; and response to bacterium. Located in extracellular space. Is expressed in organism; seminal receptacle; spermathecum; and yolk nucleus. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 63D2-63D2; 3-8 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3369556..3369942)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3369556..3369942)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster.
Title: Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster.
Tissue-autonomous immune response regulates stress signaling during hypertrophy.
Title: Tissue-autonomous immune response regulates stress signaling during hypertrophy.
in this study drosomycin is identified as the target of miR-964
Title: Drosophila miR-964 modulates Toll signaling pathway in response to bacterial infection.
These results, not only revealed a novel function and modulation pattern of miR-958, but also provided a new insight into the underlying molecular mechanisms of Toll signaling in regulation of innate immunity.
Title: miR-958 inhibits Toll signaling and Drosomycin expression via direct targeting of Toll and Dif in Drosophila melanogaster.
In 14-3-3epsilon mutants, there was a reduced release of the anti-microbial peptide Drosomycin into the haemolymph
Title: Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity.
identified five cationic residues (R6, K8, R20, R21 and K38) whose alterations significantly affected the antifungal activity
Title: Functional role of charged residues in drosomycin, a Drosophila antifungal peptide.
Expression of the AMP gene drosomycin (a Toll target) was blocked when expression of the Toll ligand Spatzle was knocked down in haemocytes.
Title: Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes.
Similarity in sequence, structure and biological activity suggests that drosomycin and some defensin molecules from plants and fungi could originate from a common ancestor.
Title: Drosomycin, an essential component of antifungal defence in Drosophila.
Drosomycin interacts with the voltage-gated sodium channel, DmNa(v)1.
Title: Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel.
DEAF-1 activates the expression of Mtk and Drs promoter.
Title: DEAF-1 regulates immunity gene expression in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	TAS Traceable Author Statement more info	PubMed
involved_in antifungal humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in antifungal humoral response	IEP Inferred from Expression Pattern more info	PubMed
involved_in antifungal humoral response	TAS Traceable Author Statement more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	TAS Traceable Author Statement more info	PubMed
involved_in defense response to fungus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to fungus	TAS Traceable Author Statement more info	PubMed
involved_in defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in response to bacterium	HEP more info	PubMed
involved_in response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: drosomycin

Names: CG10810-PA; Cysteine-rich-protein; Drosomycin-B; Drs-PA; cysteine-rich peptide; drosomcycin; drosomyci; drosomycin precursor; drosomycine; drosomyocin; drosomysin; drosophila immune induced molecule 19; immune induced molecule 21