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CG14969 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38415, updated on 14-Nov-2024

Summary

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Official Symbol
CG14969provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035440
Locus tag
Dmel_CG14969
See related
AllianceGenome:FB:FBgn0035440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14969
Summary
Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 5. Orthologous to human OSTM1 (osteoclastogenesis associated transmembrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG14969 in Genome Data Viewer
Location:
63D1-63D1; 3-8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3333119..3334978, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3333119..3334978, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Striatin interacting protein Neighboring gene Glutathione peroxidase homolog with thioredoxin peroxidase activity Neighboring gene long non-coding RNA:CR45380 Neighboring gene uncharacterized protein Neighboring gene Drosomycin-like 1 Neighboring gene Drosomycin-like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi responses. Tanaka T, et al. Nat Commun, 2024 Aug 14. PMID 39143098, Free PMC Article
  2. Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster. Parker GA, et al. G3 (Bethesda), 2020 Mar 5. PMID 31969430, Free PMC Article
  3. Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Friedman AA, et al. Sci Signal, 2011 Oct 25. PMID 22028469, Free PMC Article
  4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
  5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in lysosomal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transmembrane transporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG14969-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3333119..3334978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139552.3 → NP_647809.3  uncharacterized protein Dmel_CG14969 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647809.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SH7, Q9VZQ6
    Related
    FBpp0072944
    Conserved Domains (1) summary
    pfam09777
    Location:29 → 231
    OSTMP1; Osteopetrosis-associated transmembrane protein 1 precursor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SH7 Q95SH7

Gene LinkOut

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