Gtpx - Glutathione peroxidase homolog with thioredoxin peroxidase activity
Enables peroxidase activity. Involved in intestinal stem cell homeostasis; response to endoplasmic reticulum stress; and response to oxidative stress. Located in Golgi apparatus. Is expressed in several structures, including circulatory system; embryonic/larval fat body; embryonic/larval oenocyte; extended germ band embryo; and yolk nucleus. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Sedaghatian type. Orthologous to several human genes including GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Apr 2022]
NCBI Orthologs
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Protein alignment
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