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nSMase neutral sphingomyelinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38396, updated on 2-Nov-2024

Summary

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Official Symbol
nSMaseprovided by FlyBase
Official Full Name
neutral sphingomyelinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0035421
Locus tag
Dmel_CG12034
See related
AllianceGenome:FB:FBgn0035421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12034; Dmel\CG12034; nsmase
Summary
Predicted to enable sphingomyelin phosphodiesterase activity. Predicted to be involved in ceramide biosynthetic process; sphingolipid catabolic process; and sphingomyelin metabolic process. Predicted to be active in caveola and endoplasmic reticulum. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and mesoderm. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See nSMase in Genome Data Viewer
Location:
63B14-63B14; 3-6 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3219156..3220925)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3219156..3220925)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene gryzun Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hobbit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles. Jewett KA, et al. PLoS Genet, 2021 Feb. PMID 33539341, Free PMC Article
  2. PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability. Fevga C, et al. Brain, 2023 Apr 19. PMID 36073231, Free PMC Article
  3. Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants. Hebbar S, et al. Sci Rep, 2015 Dec 7. PMID 26639035, Free PMC Article
  4. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article
  5. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Renault AD, et al. Mech Dev, 2002 Dec. PMID 14516700

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables neutral sphingomyelin phosphodiesterase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables sphingomyelin phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingomyelin phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingomyelin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in caveola IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neutral sphingomyelinase
Names
CG12034-PA
nSMase-PA
neutral-sphingomyelinase
NP_647790.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3219156..3220925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139533.4 → NP_647790.1  neutral sphingomyelinase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647790.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q961B4, Q9VZS6
    Related
    FBpp0072907
    Conserved Domains (1) summary
    cl00490
    Location:12 → 267
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZS6.2 Q9VZS6

Gene LinkOut

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