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Usp5 Ubiquitin specific protease 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38375, updated on 2-Nov-2024

Summary

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Official Symbol
Usp5provided by FlyBase
Official Full Name
Ubiquitin specific protease 5provided by FlyBase
Primary source
FLYBASE:FBgn0035402
Locus tag
Dmel_CG12082
See related
AllianceGenome:FB:FBgn0035402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1208; CG12082; Dmel\CG12082; DmUsp5; DmUSP5; leon; Q9VZU7; usp5; USP5
Summary
Enables K48-linked deubiquitinase activity. Involved in several processes, including free ubiquitin chain depolymerization; negative regulation of JNK cascade; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human USP13 (ubiquitin specific peptidase 13) and USP5 (ubiquitin specific peptidase 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Usp5 in Genome Data Viewer
Location:
63B6-63B7; 3-6 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3145405..3148358, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3145405..3148358, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45819 Neighboring gene ALG2, alpha-1,3/1,6-mannosyltransferase Neighboring gene BTB-protein-VII Neighboring gene NADH dehydrogenase (ubiquinone) 30 kDa subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental and tissue specific changes of ubiquitin forms in Drosophila melanogaster. Nagy Á, et al. PLoS One, 2018. PMID 30543682, Free PMC Article
  2. The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development. Ling X, et al. FEBS Lett, 2017 Mar. PMID 28140449
  3. Drosophila USP5 controls the activation of apoptosis and the Jun N-terminal kinase pathway during eye development. Fan X, et al. PLoS One, 2014. PMID 24643212, Free PMC Article
  4. Role of the deubiquitylating enzyme DmUsp5 in coupling ubiquitin equilibrium to development and apoptosis in Drosophila melanogaster. Kovács L, et al. PLoS One, 2015. PMID 25806519, Free PMC Article
  5. fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila. Yagi Y, et al. Genes Cells, 2013 Nov. PMID 23919485

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster.
    Title: Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster.
  2. Thus, the deubiquitinase Leon maintains ubiquitin homeostasis and proper Ubiquilin levels, preventing postsynaptic proteins from accumulation to confine postsynaptic growth.
    Title: USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin.
  3. Loss of Usp5 results in upregulation of Notch signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
    Title: The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development.
  4. work indicates that a primary physiological role of USP5 is not to recycle monoubiquitin for reutilization, but that it may involve disassembly of conjugated ubiquitin to maintain proteasome function.
    Title: USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila.
  5. USP5 regulates ubiquitin homeostasis during Drosophila development.
    Title: The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development.
  6. Drosophila USP5 deletion phenotypes are caused by the activation of apoptosis and JNK pathway.
    Title: Drosophila USP5 controls the activation of apoptosis and the Jun N-terminal kinase pathway during eye development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in compound eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in free ubiquitin chain depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteasome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin specific protease 5
Names
CG12082-PA
CG12082-PB
CG12082-PC
Usp5-PA
Usp5-PB
Usp5-PC
isopeptidase T
NP_001246589.1
NP_001334708.1
NP_647773.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3145405..3148358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259660.2 → NP_001246589.1  ubiquitin specific protease 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246589.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZU7
    Conserved Domains (5) summary
    COG5207
    Location:24 → 825
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02658
    Location:333 → 823
    Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14294
    Location:631 → 674
    UBA1_UBP5_like; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase UBP5, UBP13 and similar proteins
    cd14386
    Location:696 → 737
    UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)
    pfam02148
    Location:204 → 278
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. NM_139516.1 → NP_647773.1  ubiquitin specific protease 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647773.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZU7
    Related
    FBpp0072976, FBtr0073114
    Conserved Domains (5) summary
    COG5207
    Location:24 → 825
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02658
    Location:333 → 823
    Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14294
    Location:631 → 674
    UBA1_UBP5_like; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase UBP5, UBP13 and similar proteins
    cd14386
    Location:696 → 737
    UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)
    pfam02148
    Location:204 → 278
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  3. NM_001347744.1 → NP_001334708.1  ubiquitin specific protease 5, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZU7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZU7 Q9VZU7

Gene LinkOut

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