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Mrtf - Myocardin-related transcription factor

Enables DNA-binding transcription factor binding activity and transcription coactivator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including ameboidal-type cell migration; cellular response to hypoxia; and imaginal disc-derived wing morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval muscle cell and ovary. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia; congenital megabladder; and immunodeficiency 66. Orthologous to several human genes including MYOCD (myocardin) and MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Apr 2022]

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Species Gene Architecture aa