Mrtf Myocardin-related transcription factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mrtfprovided by FlyBase
Official Full Name: Myocardin-related transcription factorprovided by FlyBase
Primary source: FLYBASE:FBgn0052296
Locus tag: Dmel_CG32296
See related: AllianceGenome:FB:FBgn0052296
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12188; CG14951; CG32296; Dmel\CG32296; dMrtf; dMRTF; DMRTF; mal; mal-d; Mal-D; MAL-D; MRTF
Summary: Enables DNA-binding transcription factor binding activity and transcription coactivator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including ameboidal-type cell migration; cellular response to hypoxia; and imaginal disc-derived wing morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval muscle cell and ovary. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia; congenital megabladder; and immunodeficiency 66. Orthologous to several human genes including MYOCD (myocardin) and MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (2717615..2766536, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (2717615..2766480, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: CG32296-PD; CG32296-PG; CG32296-PH; Mrtf-PD; Mrtf-PG; Mrtf-PH; myocardin-related transcription factor

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