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H3f4 H3.4 histone, cluster member [ Mus musculus (house mouse) ]

Gene ID: 382523, updated on 16-Oct-2024

Summary

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Official Symbol
H3f4provided by MGI
Official Full Name
H3.4 histone, cluster memberprovided by MGI
Primary source
MGI:MGI:3651326
See related
Ensembl:ENSMUSG00000080152 AllianceGenome:MGI:3651326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H3t; H304; H3mmT; Gm12260
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Dec 2015]
Orthologs
human all
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Genomic context

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See H3f4 in Genome Data Viewer
Location:
11 B1.3; 11 36.39 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58852537..58853099)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58961711..58962273)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E114 Neighboring gene STARR-positive B cell enhancer ABC_E5230 Neighboring gene STARR-positive B cell enhancer ABC_E6989 Neighboring gene RIKEN cDNA 2310058D17 gene Neighboring gene H2B clustered histone 26 Neighboring gene H2A clustered histone 25 Neighboring gene tripartite motif-containing 17 Neighboring gene STARR-seq mESC enhancer starr_29613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58796334-58796535 Neighboring gene tripartite motif-containing 11 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene predicted gene 10435

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice. Kawaguchi T, et al. Sci Rep, 2024 Sep 12. PMID 39266663, Free PMC Article
  2. Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis. Ueda J, et al. Cell Rep, 2017 Jan 17. PMID 28099840
  3. Tissue-specific expression of histone H3 variants diversified after species separation. Maehara K, et al. Epigenetics Chromatin, 2015. PMID 26388943, Free PMC Article
  4. Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis. Govin J, et al. J Cell Biol, 2007 Jan 29. PMID 17261847, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
uncharacterized protein LOC382523
Names
H3.4 histone
histone cluster 1, H3 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318003.2 → NP_001304932.1  uncharacterized protein LOC382523

    Status: REVIEWED

    Source sequence(s)
    AL662809
    UniProtKB/TrEMBL
    A0A8I4SYN6, A1L0V4
    Related
    ENSMUSP00001091671.1, ENSMUST00000122447.3
    Conserved Domains (1) summary
    PTZ00018
    Location:1 → 136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58852537..58853099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_008452.1: Suppressed sequence

    Description
    NG_008452.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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