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Tcaim T cell activation inhibitor, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 382117, updated on 2-Nov-2024

Summary

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Official Symbol
Tcaimprovided by MGI
Official Full Name
T cell activation inhibitor, mitochondrialprovided by MGI
Primary source
MGI:MGI:1196217
See related
Ensembl:ENSMUSG00000046603 AllianceGenome:MGI:1196217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1129; TOAG-1; D9Ertd402e
Summary
Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human TCAIM (T cell activation inhibitor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 4.1), kidney adult (RPKM 3.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Tcaim in Genome Data Viewer
Location:
9 F4; 9 73.14 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122634586..122665397)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122805513..122838924)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51699 Neighboring gene testis and ovary specific PAZ domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:122694321-122694622 Neighboring gene STARR-positive B cell enhancer ABC_E6814 Neighboring gene predicted gene, 35549 Neighboring gene zinc finger protein 445 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122775118-122775301 Neighboring gene zinc finger with KRAB and SCAN domains 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production. Vogel SZ, et al. J Immunol, 2015 Apr 1. PMID 25750433
  2. Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies. Keeren K, et al. J Immunol, 2009 Sep 15. PMID 19684086
  3. Identification of gene markers for the prediction of allograft rejection or permanent acceptance. Sawitzki B, et al. Am J Transplant, 2007 May. PMID 17456197
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production.
    Title: TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production.
  2. Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro.
    Title: Identification of gene markers for the prediction of allograft rejection or permanent acceptance.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC91156

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-cell activation inhibitor, mitochondrial
Names
tolerance associated gene-1 protein
tolerance-associated gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013405.3 → NP_001013423.3  T-cell activation inhibitor, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125374
    Consensus CDS
    CCDS23647.2
    UniProtKB/Swiss-Prot
    Q66JZ4
    Related
    ENSMUSP00000049759.8, ENSMUST00000052740.14

  2. NM_001408934.1 → NP_001395863.1  T-cell activation inhibitor, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125374
    UniProtKB/Swiss-Prot
    Q66JZ4

  3. NM_001408935.1 → NP_001395864.1  T-cell activation inhibitor, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125374

  4. NM_001408936.1 → NP_001395865.1  T-cell activation inhibitor, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125374

  5. NM_001408937.1 → NP_001395866.1  T-cell activation inhibitor, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125374

  6. NM_001408938.1 → NP_001395867.1  T-cell activation inhibitor, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125374

  7. NM_001408939.1 → NP_001395868.1  T-cell activation inhibitor, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125374

  8. NM_001408940.1 → NP_001395869.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125374

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    122634586..122665397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512171.5 → XP_006512234.1  T-cell activation inhibitor, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006512234.1

    UniProtKB/TrEMBL
    G3X983
    Conserved Domains (2) summary
    pfam14687
    Location:60 → 166
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:227 → 529
    DUF4461; Domain of unknown function (DUF4461)

  2. XM_017313450.3 → XP_017168939.1  T-cell activation inhibitor, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam14688
    Location:90 → 392
    DUF4461; Domain of unknown function (DUF4461)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66JZ4.1 GenPept UniProtKB/Swiss-Prot:Q66JZ4

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