Gm1123 predicted gene 1123 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gm1123provided by MGI
Official Full Name: predicted gene 1123provided by MGI
Primary source: MGI:MGI:2685969
See related: Ensembl:ENSMUSG00000044860 AllianceGenome:MGI:2685969
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLSP
Summary: Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in homotypic cell-cell adhesion. Predicted to be active in basolateral plasma membrane; bicellular tight junction; and intercalated disc. Is expressed in face. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 147.4), colon adult (RPKM 47.6) and 2 other tissues See more
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Genomic context

Location:: 9 E3.3; 9 51.41 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (98889018..98917743, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (99006965..99035690, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLSP is a physiological heterotrimeric humanin receptor agonist.
Title: Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.
These results suggest that CLSP may play a role in the antiviral defense of the host in rodent animals.
Title: Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP.
The coxsackie- and adenovirus receptor is localized to epithelial tight junctions in vivo where it may play a role in the regulation of epithelial permeability and tissue homeostasis.
Title: The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis.

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General gene information

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Markers

D9Dcr31 (e-PCR), detects polymorphism
- UniSTS:498948

D9Mit199 (e-PCR), detects polymorphism
- UniSTS:116784

NoName (e-PCR)
- UniSTS:487839

NoName (e-PCR)
- UniSTS:236232

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in homotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: coxsackie adenovirus receptor-like

Names: CAR-like soluble protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.