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Spef1l sperm flagellar 1 like [ Mus musculus (house mouse) ]

Gene ID: 381933, updated on 2-Nov-2024

Summary

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Official Symbol
Spef1lprovided by MGI
Official Full Name
sperm flagellar 1 likeprovided by MGI
Primary source
MGI:MGI:2685939
See related
Ensembl:ENSMUSG00000073795 AllianceGenome:MGI:2685939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1093; 6430531B16Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in regulation of cytoskeleton organization. Predicted to be active in axoneme. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 41.4), ovary adult (RPKM 2.7) and 1 other tissue See more
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Genomic context

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See Spef1l in Genome Data Viewer
Location:
7 F4; 7 84.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139552211..139558668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139972298..139978755, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16201 Neighboring gene microRNA 7686 Neighboring gene microRNA 202 Neighboring gene STARR-positive B cell enhancer ABC_E10482 Neighboring gene STARR-positive B cell enhancer ABC_E11374 Neighboring gene a disintegrin and metallopeptidase domain 8 Neighboring gene microRNA 7062 Neighboring gene STARR-seq mESC enhancer starr_20441 Neighboring gene tubulin, gamma complex component 2 Neighboring gene STARR-seq mESC enhancer starr_20442 Neighboring gene STARR-positive B cell enhancer ABC_E6615 Neighboring gene STARR-positive B cell enhancer ABC_E8219 Neighboring gene zinc finger protein 511

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC381933

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033465.3 → NP_001028637.1  uncharacterized protein LOC381933 isoform 1

    See identical proteins and their annotated locations for NP_001028637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK131789, BF152936
    Consensus CDS
    CCDS40172.1
    UniProtKB/TrEMBL
    Q3V2J1
    Related
    ENSMUSP00000095584.3, ENSMUST00000097970.9
    Conserved Domains (1) summary
    pfam06294
    Location:23 → 113
    CH_2; CH-like domain in sperm protein

  2. NM_001347613.2 → NP_001334542.1  uncharacterized protein LOC381933 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction and lacks an alternate coding exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC107822
    Consensus CDS
    CCDS85450.1
    UniProtKB/TrEMBL
    A0A1B0GR09, Q3TNW9
    Related
    ENSMUSP00000147330.2, ENSMUST00000210254.2

  3. NM_001347614.2 → NP_001334543.1  uncharacterized protein LOC381933 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC107822
    Consensus CDS
    CCDS85449.1
    UniProtKB/TrEMBL
    A0A1B0GT96, Q3TNW9
    Related
    ENSMUSP00000148257.2, ENSMUST00000209335.2

  4. NM_001359836.1 → NP_001346765.1  uncharacterized protein LOC381933 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC107822
    UniProtKB/TrEMBL
    Q3TNW9
    Conserved Domains (1) summary
    pfam06294
    Location:22 → 113
    CH_2; CH-like domain in sperm protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139552211..139558668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153205.1 → XP_036009098.1  uncharacterized protein LOC381933 isoform X2

  2. XM_036153204.1 → XP_036009097.1  uncharacterized protein LOC381933 isoform X1

    UniProtKB/TrEMBL
    Q3TNW9
    Related
    ENSMUSP00000113338.2, ENSMUST00000121412.2
    Conserved Domains (1) summary
    pfam06294
    Location:22 → 113
    CH_2; CH-like domain in sperm protein
Nucleotide Protein Strain
Heading Accession and Version

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