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Ovol3 ovo like zinc finger 3 [ Mus musculus (house mouse) ]

Gene ID: 381867, updated on 2-Nov-2024

Summary

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Official Symbol
Ovol3provided by MGI
Official Full Name
ovo like zinc finger 3provided by MGI
Primary source
MGI:MGI:2388075
See related
Ensembl:ENSMUSG00000100512 AllianceGenome:MGI:2388075
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
movo3; Gm1903
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epidermal cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human OVOL3 (ovo like zinc finger 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 1.6), stomach adult (RPKM 1.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ovol3 in Genome Data Viewer
Location:
7 B1; 7 17.34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29932722..29937000, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30233297..30237575, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18511 Neighboring gene STARR-positive B cell enhancer ABC_E6531 Neighboring gene STARR-positive B cell enhancer ABC_E6532 Neighboring gene calpain, small subunit 1 Neighboring gene STARR-seq mESC enhancer starr_18512 Neighboring gene STARR-positive B cell enhancer ABC_E4915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31016881-31016990 Neighboring gene tubulin folding cofactor B Neighboring gene polymerase (RNA) II (DNA directed) polypeptide I Neighboring gene WD repeat domain 62 Neighboring gene ribosomal protein S12, pseudogene 5 Neighboring gene RIKEN cDNA 1700020L13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:31065285-31065586 Neighboring gene THAP domain containing 8, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. Li B, et al. Genomics, 2002 Sep. PMID 12213202, Free PMC Article
  2. Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions. Kumar A, et al. PLoS One, 2012. PMID 22737237, Free PMC Article
  3. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Li B, et al. Development, 2005 Mar. PMID 15716349, Free PMC Article
  4. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epidermal cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative transcription factor ovo-like protein 3
Names
OVO homolog-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289817.1 → NP_001276746.1  putative transcription factor ovo-like protein 3

    See identical proteins and their annotated locations for NP_001276746.1

    Status: PROVISIONAL

    Source sequence(s)
    AC149067
    Consensus CDS
    CCDS80691.1
    UniProtKB/Swiss-Prot
    D3YYM0
    Related
    ENSMUSP00000140811.2, ENSMUST00000189482.2
    Conserved Domains (3) summary
    sd00017
    Location:71 → 91
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:97 → 119
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:111 → 136
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29932722..29937000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153197.1 → XP_036009090.1  putative transcription factor ovo-like protein 3 isoform X1

    UniProtKB/Swiss-Prot
    D3YYM0
    Conserved Domains (3) summary
    sd00017
    Location:71 → 91
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:97 → 119
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:111 → 136
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YYM0.2 GenPept UniProtKB/Swiss-Prot:D3YYM0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials