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Mroh7 maestro heat-like repeat family member 7 [ Mus musculus (house mouse) ]

Gene ID: 381538, updated on 28-Oct-2024

Summary

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Official Symbol
Mroh7provided by MGI
Official Full Name
maestro heat-like repeat family member 7provided by MGI
Primary source
MGI:MGI:2685873
See related
Ensembl:ENSMUSG00000047502 AllianceGenome:MGI:2685873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1027; Heatr8
Summary
Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human MROH7 (maestro heat like repeat family member 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 58.4) and large intestine adult (RPKM 2.6) See more
Orthologs
human all
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Genomic context

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See Mroh7 in Genome Data Viewer
Location:
4 C7; 4 49.69 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106537614..106595059, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106680417..106736534, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2700 Neighboring gene prolyl-tRNA synthetase (mitochondrial)(putative) Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene STARR-positive B cell enhancer ABC_E6195 Neighboring gene family with sequence simliarity 151, member A Neighboring gene acyl-CoA thioesterase 11 Neighboring gene STARR-positive B cell enhancer ABC_E4640 Neighboring gene predicted gene, 31065

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. Suzuki A, et al. J Reprod Immunol, 2024 Jun. PMID 38697008,
  2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
maestro heat-like repeat-containing protein family member 7
Names
HEAT repeat-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126487.1 → NP_001119959.1  maestro heat-like repeat-containing protein family member 7

    See identical proteins and their annotated locations for NP_001119959.1

    Status: VALIDATED

    Source sequence(s)
    AL929585
    Consensus CDS
    CCDS51253.1
    UniProtKB/Swiss-Prot
    A2AVR2
    Related
    ENSMUSP00000102382.2, ENSMUST00000106770.8
    Conserved Domains (1) summary
    pfam06566
    Location:26 → 168
    Chon_Sulph_att; Chondroitin sulphate attachment domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    106537614..106595059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240561.4 → XP_011238863.1  maestro heat-like repeat-containing protein family member 7 isoform X1

    See identical proteins and their annotated locations for XP_011238863.1

    UniProtKB/Swiss-Prot
    A2AVR2
    Conserved Domains (1) summary
    pfam06566
    Location:26 → 168
    Chon_Sulph_att; Chondroitin sulphate attachment domain

  2. XM_011240562.3 → XP_011238864.1  maestro heat-like repeat-containing protein family member 7 isoform X1

    See identical proteins and their annotated locations for XP_011238864.1

    UniProtKB/Swiss-Prot
    A2AVR2
    Conserved Domains (1) summary
    pfam06566
    Location:26 → 168
    Chon_Sulph_att; Chondroitin sulphate attachment domain

  3. XM_011240564.1 → XP_011238866.1  maestro heat-like repeat-containing protein family member 7 isoform X4

    Conserved Domains (1) summary
    pfam06566
    Location:26 → 168
    Chon_Sulph_att; Chondroitin sulphate attachment domain

  4. XM_011240563.1 → XP_011238865.1  maestro heat-like repeat-containing protein family member 7 isoform X2

    Conserved Domains (1) summary
    pfam06566
    Location:26 → 168
    Chon_Sulph_att; Chondroitin sulphate attachment domain

  5. XM_036164208.1 → XP_036020101.1  maestro heat-like repeat-containing protein family member 7 isoform X3

    Conserved Domains (1) summary
    PHA03307
    Location:15 → 168
    PHA03307; transcriptional regulator ICP4; Provisional

  6. XM_006503201.1 → XP_006503264.1  maestro heat-like repeat-containing protein family member 7 isoform X1

    See identical proteins and their annotated locations for XP_006503264.1

    UniProtKB/Swiss-Prot
    A2AVR2
    Conserved Domains (1) summary
    pfam06566
    Location:26 → 168
    Chon_Sulph_att; Chondroitin sulphate attachment domain

  7. XM_011240565.1 → XP_011238867.1  maestro heat-like repeat-containing protein family member 7 isoform X5

    Conserved Domains (1) summary
    pfam06566
    Location:37 → 168
    Chon_Sulph_att; Chondroitin sulphate attachment domain

  8. XM_011240566.3 → XP_011238868.1  maestro heat-like repeat-containing protein family member 7 isoform X6

    Conserved Domains (1) summary
    pfam06566
    Location:37 → 168
    Chon_Sulph_att; Chondroitin sulphate attachment domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AVR2.1 GenPept UniProtKB/Swiss-Prot:A2AVR2

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