S100a7a S100 calcium binding protein A7A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a7aprovided by MGI
Official Full Name: S100 calcium binding protein A7Aprovided by MGI
Primary source: MGI:MGI:2687194
See related: Ensembl:ENSMUSG00000063767 AllianceGenome:MGI:2687194
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1020; S100A7f; S100a15; S100A7L1; S100a15a; S100a17l1
Summary: Enables chemoattractant activity. Acts upstream of or within inflammatory response. Located in extracellular space. Is expressed in central nervous system. Used to study psoriasis. Orthologous to human S100A7 (S100 calcium binding protein A7); S100A7L2 (S100 calcium binding protein A7 like 2); and S100A7A (S100 calcium binding protein A7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 1.5), lung adult (RPKM 0.7) and 13 other tissues See more
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Genomic context

Location:: 3 F1; 3 39.82 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90561609..90565437)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90651925..90658130)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

visfatin enhances CAMP, hBD-2, hBD-3, and S100A7 production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin.
Title: Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin.
Data show that hS100A7 and mS100a7a15 overexpression induce proliferation and expression of inflammatory cytokines/chemokines.
Title: S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.
These results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. S00A7
Title: Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis.
The regulation, expression pattern and crosslinking of mS100A15 are consistent with the characteristics of the human orthologs, providing a valid surrogate model to study changes in these proteins associated with cutaneous pathologies.
Title: The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493093

NoName (e-PCR)
- UniSTS:490547

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion sequestering activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A15A

Names: S100 calcium binding protein A15; S100 calcium binding protein A7-like 1; S100 calcium-binding protein A15A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199422.1 → NP_955454.1 protein S100-A15A

See identical proteins and their annotated locations for NP_955454.1

Status: PROVISIONAL

Source sequence(s)

AY465109

Consensus CDS

CCDS17541.1

UniProtKB/Swiss-Prot

Q6S5I3

Related

ENSMUSP00000078268.3, ENSMUST00000079286.4

Conserved Domains (1) summary

cd00213
Location:4 → 93

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...