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Zfp663 zinc finger protein 663 [ Mus musculus (house mouse) ]

Gene ID: 381405, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp663provided by MGI
Official Full Name
zinc finger protein 663provided by MGI
Primary source
MGI:MGI:2685854
See related
Ensembl:ENSMUSG00000056824 AllianceGenome:MGI:2685854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1008
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; ganglia; glans of male genital tubercle; retina; and skeletal musculature. Orthologous to human ZNF663P (zinc finger protein 663, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E14 (RPKM 1.2), whole brain E14.5 (RPKM 1.1) and 6 other tissues See more
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Genomic context

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See Zfp663 in Genome Data Viewer
Location:
2 H3; 2 85.53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165193217..165210656, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165351297..165368736, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member C2 Neighboring gene engulfment and cell motility 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165147221-165147404 Neighboring gene STARR-positive B cell enhancer ABC_E418 Neighboring gene predicted gene, 29831 Neighboring gene STARR-seq mESC enhancer starr_06348 Neighboring gene zinc finger protein 334 Neighboring gene osteoclast stimulatory transmembrane protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Homology

Clone Names

  • MGC86131

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 663

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005425.2 → NP_001005425.1  zinc finger protein 663 isoform a

    See identical proteins and their annotated locations for NP_001005425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AL591064, AL591430
    Consensus CDS
    CCDS17078.1
    UniProtKB/TrEMBL
    Q6NXM6
    Related
    ENSMUSP00000099374.2, ENSMUST00000103085.8
    Conserved Domains (5) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:456 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528 → 550
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:598 → 623
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001379474.1 → NP_001366403.1  zinc finger protein 663 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AL591064, AL591430
    UniProtKB/TrEMBL
    Q6NXM6
    Conserved Domains (5) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:456 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528 → 550
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:598 → 623
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001379475.1 → NP_001366404.1  zinc finger protein 663 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AL591064, AL591430
    UniProtKB/TrEMBL
    Q6NXM6
    Related
    ENSMUSP00000072813.8, ENSMUST00000073062.14
    Conserved Domains (5) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:456 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528 → 550
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:598 → 623
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001379476.1 → NP_001366405.1  zinc finger protein 663 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL591064, AL591430
    Conserved Domains (5) summary
    COG5048
    Location:420 → 495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:492 → 514
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:562 → 587
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1 → 31
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165193217..165210656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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