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Iars2 isoleucine-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 381314, updated on 3-Nov-2024

Summary

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Official Symbol
Iars2provided by MGI
Official Full Name
isoleucine-tRNA synthetase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:1919586
See related
Ensembl:ENSMUSG00000026618 AllianceGenome:MGI:1919586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010002H18Rik
Summary
Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 24.1), subcutaneous fat pad adult (RPKM 16.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Iars2 in Genome Data Viewer
Location:
1 H5; 1 89.48 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (185018839..185061615, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (185286642..185329419, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RAB3 GTPase activating protein subunit 2 Neighboring gene small nucleolar RNA, H/ACA box 36B Neighboring gene predicted gene, 34882 Neighboring gene microRNA 664 Neighboring gene RIKEN cDNA 2010103J01 gene Neighboring gene microRNA 194-1 Neighboring gene STARR-seq mESC enhancer starr_03326 Neighboring gene microRNA 215 Neighboring gene STARR-seq mESC enhancer starr_03328 Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4403 Neighboring gene STARR-positive B cell enhancer ABC_E3350 Neighboring gene glutamyl-prolyl-tRNA synthetase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
  2. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC63429

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isoleucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
isoleucine--tRNA ligase, mitochondrial
Names
ileRS
isoleucyl-tRNA synthetase, mitochondrial
NP_941055.1
XP_006497242.1
XP_006497243.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198653.3 → NP_941055.1  isoleucine--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_941055.1

    Status: VALIDATED

    Source sequence(s)
    AK043590, AK048653
    Consensus CDS
    CCDS15596.1
    UniProtKB/Swiss-Prot
    Q3TKT8, Q8BIJ0, Q8BIJ6, Q8BIP3
    Related
    ENSMUSP00000027921.5, ENSMUST00000027921.11
    Conserved Domains (5) summary
    cd07960
    Location:711 → 890
    Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
    PRK05743
    Location:60 → 1009
    ileS; isoleucyl-tRNA synthetase; Reviewed
    pfam06827
    Location:985 → 1006
    zf-FPG_IleRS; Zinc finger found in FPG and IleRS
    pfam13603
    Location:266 → 412
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
    cl00015
    Location:472 → 708
    nt_trans; nucleotidyl transferase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    185018839..185061615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497180.5 → XP_006497243.1  isoleucine--tRNA ligase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006497243.1

    UniProtKB/TrEMBL
    E9PWN3, Q8BIL6
    Conserved Domains (1) summary
    PRK05743
    Location:60 → 546
    ileS; isoleucyl-tRNA synthetase; Reviewed

  2. XM_006497179.5 → XP_006497242.1  isoleucine--tRNA ligase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006497242.1

    UniProtKB/TrEMBL
    E9PWN3, Q8BIL6
    Related
    ENSMUSP00000106601.4, ENSMUST00000110974.4
    Conserved Domains (1) summary
    PRK05743
    Location:60 → 546
    ileS; isoleucyl-tRNA synthetase; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIJ6.1 GenPept UniProtKB/Swiss-Prot:Q8BIJ6

Gene LinkOut

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