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Trhn - Tryptophan hydroxylase neuronal

Enables phenylalanine 4-monooxygenase activity and tryptophan 5-monooxygenase activity. Involved in several processes, including regulation of circadian sleep/wake cycle, sleep; serotonin biosynthetic process; and tracheal pit formation in open tracheal system. Predicted to be active in neuron projection. Is expressed in several structures, including adult abdomen; central nervous system; embryonic/larval nervous system; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; autistic disorder; borderline personality disorder; and mental depression (multiple). Orthologous to several human genes including TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

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Species Gene Architecture aa