Trhn Tryptophan hydroxylase neuronal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Trhnprovided by FlyBase
Official Full Name: Tryptophan hydroxylase neuronalprovided by FlyBase
Primary source: FLYBASE:FBgn0035187
Locus tag: Dmel_CG9122
See related: AllianceGenome:FB:FBgn0035187
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9122; CT9937; Dmel\CG9122; dTrh; DTRH; DTRHn; trh; Trh; TrH; TRH; TRHn
Summary: Enables phenylalanine 4-monooxygenase activity and tryptophan 5-monooxygenase activity. Involved in several processes, including regulation of circadian sleep/wake cycle, sleep; serotonin biosynthetic process; and tracheal pit formation in open tracheal system. Predicted to be active in neuron projection. Is expressed in several structures, including adult abdomen; central nervous system; embryonic/larval nervous system; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; autistic disorder; borderline personality disorder; and mental depression (multiple). Orthologous to several human genes including TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 61F3-61F3; 3-0 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1190384..1193173, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1190384..1193173, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DTRH may be primarily neuronal in function and expression, and serve as an ancient conserved mechanism to appropriately regulate the production of serotonin in its target tissues.
Title: Serotonin synthesis by two distinct enzymes in Drosophila melanogaster.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables phenylalanine 4-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables tryptophan 5-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 5-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables tryptophan 5-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 5-monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in serotonin biosynthetic process from tryptophan	IEP Inferred from Expression Pattern more info	PubMed
involved_in serotonin biosynthetic process from tryptophan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal pit formation in open tracheal system	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tryptophan hydroxylase neuronal

Names: CG9122-PA; Trhn-PA; tryptophan hydroxylase

NP_612080.1

EC 1.14.16.-

EC 1.14.16.1

EC 1.14.16.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1190384..1193173 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_138236.2 → NP_612080.1 tryptophan hydroxylase neuronal [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_612080.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W0K2

Related

FBpp0072534

Conserved Domains (3) summary

TIGR01270
Location:34 → 509

Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric

cd04929
Location:79 → 152

ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes

pfam00351
Location:177 → 506

Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase