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Usp10 Ubiquitin specific protease 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38103, updated on 2-Nov-2024

Summary

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Official Symbol
Usp10provided by FlyBase
Official Full Name
Ubiquitin specific protease 10provided by FlyBase
Primary source
FLYBASE:FBgn0052479
Locus tag
Dmel_CG32479
See related
AllianceGenome:FB:FBgn0052479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12503; CG13903; CG32479; Dmel\CG32479; Q9W0L7; usp10; USP10
Summary
Predicted to enable cysteine-type deubiquitinase activity. Involved in positive regulation of Notch signaling pathway. Located in cytosol. Is expressed in adult brain cell body rind and adult head. Orthologous to human USP10 (ubiquitin specific peptidase 10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Usp10 in Genome Data Viewer
Location:
61D2-61D4; 3-0.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (871899..895313)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (871899..895313)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 20 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Usp10 Modulates the Hippo Pathway by Deubiquitinating and Stabilizing the Transcriptional Coactivator Yorkie. Gao Y, et al. Int J Mol Sci, 2019 Nov 29. PMID 31795326, Free PMC Article
  2. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila. Farkas A, et al. Sci Rep, 2023 Dec 11. PMID 38081944, Free PMC Article
  3. RNA-binding protein Roquin negatively regulates STING-dependent innate immune response in Drosophila. Du BB, et al. Yi Chuan, 2020 Dec 17. PMID 33509784
  4. fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila. Yagi Y, et al. Genes Cells, 2013 Nov. PMID 23919485
  5. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen X, et al. Genetics, 2000 Dec. PMID 11102377, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NELF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
ubiquitin specific protease 10
Names
CG32479-PA
CG32479-PB
CG32479-PC
Usp10-PA
Usp10-PB
Usp10-PC
NP_001261228.1
NP_001261229.1
NP_728554.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    871899..895313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167844.2 → NP_728554.1  ubiquitin specific protease 10, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728554.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0L7
    Related
    FBpp0072486
    Conserved Domains (2) summary
    cd02257
    Location:1223 → 1480
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:1109 → 1479
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. NM_001274300.1 → NP_001261229.1  ubiquitin specific protease 10, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261229.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0L7
    Conserved Domains (2) summary
    cd02257
    Location:1223 → 1480
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:1109 → 1479
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. NM_001274299.1 → NP_001261228.1  ubiquitin specific protease 10, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDK3
    Conserved Domains (2) summary
    cd02257
    Location:503 → 760
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:389 → 759
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDK3 M9PDK3
Q9W0L7 Q9W0L7

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