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Nckap5l NCK-associated protein 5-like [ Mus musculus (house mouse) ]

Gene ID: 380969, updated on 2-Nov-2024

Summary

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Official Symbol
Nckap5lprovided by MGI
Official Full Name
NCK-associated protein 5-likeprovided by MGI
Primary source
MGI:MGI:3609653
See related
Ensembl:ENSMUSG00000023009 AllianceGenome:MGI:3609653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cep169; C230021P08Rik
Summary
Predicted to be involved in microtubule bundle formation and microtubule depolymerization. Predicted to be located in centrosome. Predicted to be active in microtubule plus-end. Is expressed in central nervous system and retina. Orthologous to human NCKAP5L (NCK associated protein 5 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 18.9), thymus adult (RPKM 16.2) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Nckap5l in Genome Data Viewer
Location:
15 F1; 15 56.13 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99319915..99355676, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99422034..99457938, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene formin-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3156 Neighboring gene predicted gene, 22951 Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E761 Neighboring gene VISTA enhancer mm1635 Neighboring gene NCK-associated protein 5-like, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E5516 Neighboring gene BCDIN3 domain containing Neighboring gene Fas apoptotic inhibitory molecule 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
  2. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule plus-end ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nck-associated protein 5-like
Names
centrosomal protein of 169 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001884.2 → NP_001001884.1  nck-associated protein 5-like

    See identical proteins and their annotated locations for NP_001001884.1

    Status: VALIDATED

    Source sequence(s)
    AC117831, AC118646
    Consensus CDS
    CCDS27820.1
    UniProtKB/Swiss-Prot
    Q6GQX2, Q8BX75, Q8R364
    Related
    ENSMUSP00000023747.8, ENSMUST00000023747.14
    Conserved Domains (3) summary
    PHA03247
    Location:418 → 876
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:210 → 529
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15246
    Location:871 → 1171
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  2. NM_001403554.1 → NP_001390483.1  nck-associated protein 5-like

    Status: VALIDATED

    Source sequence(s)
    AC117831, AC118646
    UniProtKB/Swiss-Prot
    Q6GQX2, Q8BX75, Q8R364

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99319915..99355676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521122.5 → XP_006521185.1  nck-associated protein 5-like isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:446 → 904
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:238 → 557
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam07926
    Location:55 → 131
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam15246
    Location:899 → 1199
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  2. XM_036159478.1 → XP_036015371.1  nck-associated protein 5-like isoform X2

    UniProtKB/Swiss-Prot
    Q6GQX2, Q8BX75, Q8R364
    Conserved Domains (3) summary
    PHA03247
    Location:418 → 876
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:210 → 529
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15246
    Location:871 → 1171
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  3. XM_036159477.1 → XP_036015370.1  nck-associated protein 5-like isoform X2

    UniProtKB/Swiss-Prot
    Q6GQX2, Q8BX75, Q8R364
    Conserved Domains (3) summary
    PHA03247
    Location:418 → 876
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:210 → 529
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15246
    Location:871 → 1171
    NCKAP5; Nck-associated protein 5, Peripheral clock protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GQX2.1 GenPept UniProtKB/Swiss-Prot:Q6GQX2

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