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Serpinb1c serine (or cysteine) peptidase inhibitor, clade B, member 1c [ Mus musculus (house mouse) ]

Gene ID: 380839, updated on 18-Sep-2024

Summary

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Official Symbol
Serpinb1cprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 1cprovided by MGI
Primary source
MGI:MGI:2445363
See related
Ensembl:ENSMUSG00000079049 AllianceGenome:MGI:2445363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EIC; ovalbumin
Summary
Predicted to enable peptidase inhibitor activity. Predicted to contribute to serine-type endopeptidase inhibitor activity. Involved in negative regulation of interleukin-1 beta production. Predicted to be located in cytoplasmic ribonucleoprotein granule and extracellular region. Predicted to be active in extracellular space. Is expressed in liver lobe. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 2.9), duodenum adult (RPKM 1.6) and 7 other tissues See more
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Genomic context

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See Serpinb1c in Genome Data Viewer
Location:
13 A3.2; 13 13.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33065201..33126773, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32881218..32940628, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Neighboring gene predicted gene, 35899 Neighboring gene nonconserved acetylation island sequence M71 enhancer Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7220 Neighboring gene STARR-seq mESC enhancer starr_34105 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6b Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:33096570-33096679 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9 Neighboring gene predicted gene, 36181

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers. Kolanowski TJ, et al. Int J Mol Sci, 2021 Nov 22. PMID 34830471, Free PMC Article
  2. Enhanced egg-induced immunopathology correlates with high IFN-gamma in murine schistosomiasis: identification of two epistatic genetic intervals. Rutitzky LI, et al. J Immunol, 2005 Jan 1. PMID 15611268
  3. SERPINB1-mediated checkpoint of inflammatory caspase activation. Choi YJ, et al. Nat Immunol, 2019 Mar. PMID 30692621, Free PMC Article
  4. Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). Benarafa C, et al. J Biol Chem, 2002 Nov 1. PMID 12189154
  5. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
    Title: Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
  2. cDNA cloning, gene structure and biological characterization homologous to human MNEI
    Title: Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC129308

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables serine-type endopeptidase inhibitor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1 beta production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leukocyte elastase inhibitor C
Names
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1c
serine (or cysteine) proteinase inhibitor, clade B, member 1c
serine protease inhibitor EIC
serpin B1c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384088.1 → NP_001371017.1  leukocyte elastase inhibitor C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589871, AL606533, AL645693
    Conserved Domains (1) summary
    cl38926
    Location:1 → 306
    serpin; SERine Proteinase INhibitors (serpin) family

  2. NM_173051.2 → NP_766639.2  leukocyte elastase inhibitor C isoform 1

    See identical proteins and their annotated locations for NP_766639.2

    Status: VALIDATED

    Source sequence(s)
    AL606533, AL645693, BC104332, CJ203237
    Consensus CDS
    CCDS26429.1
    UniProtKB/Swiss-Prot
    Q5SV42, Q5SW82, Q8K3Y1
    Related
    ENSMUSP00000021834.4, ENSMUST00000021834.11
    Conserved Domains (1) summary
    cl00137
    Location:4 → 375
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    33065201..33126773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516708.2 → XP_006516771.1  leukocyte elastase inhibitor C isoform X1

    Conserved Domains (1) summary
    cd19560
    Location:34 → 408
    serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

  2. XM_036158080.1 → XP_036013973.1  leukocyte elastase inhibitor C isoform X2

    Conserved Domains (1) summary
    cd19560
    Location:1 → 375
    serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

  3. XM_017315534.3 → XP_017171023.1  leukocyte elastase inhibitor C isoform X2

    Conserved Domains (1) summary
    cd19560
    Location:1 → 375
    serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

  4. XM_011244317.3 → XP_011242619.1  leukocyte elastase inhibitor C isoform X3

    Conserved Domains (1) summary
    cl38926
    Location:34 → 339
    serpin; SERine Proteinase INhibitors (serpin) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SV42.1 GenPept UniProtKB/Swiss-Prot:Q5SV42

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